Nicotine in the form of tobacco has been more widely used by humans than almost any other psychoactive drug. Recognition of the important role of nicotine in tobacco addiction, together with rapid advances in the techniques available to neuroscientists, has led to a great increase in research into the effects of nicotine on the central nervous system. This book consists of invited reviews from a variety of experts on many aspects of the psychopharmacology of nicotine. They integratethe present state of knowledge in this area and explore molecular, biochemical, neurophysiological, and behavioural approaches to studying nicotine and central nicotinic receptors. As well as having implications for health problems associated with tobacco use, the results have enhanced understandingof how central nicotinic mechanisms are involved in other psychiatric and neurological states, such as Parkinsons Disease and Alzheimers Disease.
Jerome H. Jaffe:: Tobacco, smoking, and nicotine dependence; Michael D.B. Swedburg, Jack E. Henningfield, & Steven R. Goldberg:: Evidence of nicotine dependency from animal studies:: self-administration, tolerance, and withdrawal; David M. Warburton:: Psychopharmacological aspects of nicotine; Neal L. Benowitz, Herve Porchet, & Peyton Jacob:: Pharmacokinetics, metabolism, and pharmacodynamics of nicotine; Paul B.S. Clarke:: The central pharmacology of nicotine::electrophysiological approaches; Kjell Fuxe, Kurt Andersson, Anders Härfstrand, Peter Eneroth, Miguel Perez de la Mora, & Luigi F. Agnati:: Effects of nicotine on synaptic transmission in the brain; S. Wonnacott:: Characterization of nicotine receptor sites in the brain; I. P. Stolerman:: Behavioural pharmacology of nicotine inanimals; C. Reavill:: Actions of nicotine on dopamine pathways and implications for Parkinsons disease; Kenneth J. Kellar & S. Wonnacott:: Nicotinic-cholinergic receptors in Alzheimers disease; M.A.H. Russell:: Nicotine intake and its control over smoking; Index.
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