Epilepsy

VOLUME I

Introduction:: What Is Epilepsy?

SECTION 1 EPIDEMIOLOGY, PATHOLOGY, AND GENETICS OF EPILEPSY

Overview:: Epidemiology, Pathology, and Genetics

Epilepsy:: Historical Perspectives Neuropathology

EPIDEMIOLOGY

Incidence and Prevalence

The Natural History and Prognosis of Epilepsy

NEUROPATHOLOGY

General Neuropathology of Epilepsy

Hippocampal Sclerosis

GENETICS

Genetic Epidemiology

EEG Traits

SECTION II THE NEUROBIOLOGY OF EPILEPSY

Overview:: The Neurobiology of Epilepsy

MECHANISMS OF NORMAL NEURONAL EXCITABILITY

Control of Neuronal Excitability

Excitatory Synaptic Transmission

Neocortical Anatomy and Physiology

Thalamocortical Anatomy and Physiology

MECHANISMS OF EPILEPTOGENESIS AND EPILEPTOGENICITY

Genetic Models of Epilepsy

Seizure Mechanisms and Vulnerability in the Developing Brain

SECTION III PHENOMENOLOGY

Overview:: Phenomenology

EPILEPTIC SEIZURES

Simple Motor Seizures

Limbic Seizures

Epileptic Spasms

STATUS EPILEPTICUS

Generalized Convulsive Status Epilepticus

Absence Status Epilepticus

Myoclonic Status Epilepticus

EPILEPTIC DISORDERS

Classification of the Epilepsies

SECTION IV DIAGNOSTIC EVALUATION

Overview:: Diagnostic Evaluation

ROUTINE INVESTIGATIONS

History and Physical Examination

EEG

Physiologic Basis of the Electroencephalogram and Local Field Potentials

Ictal Electroencephalogram

Polygraphic Recordings

NEUROIMAGING

Positron Emission Tomography

Magnetic Resonance Spectroscopy

Computational Anatomy

NEW DIRECTIONS

Seizure Prediction

Microdialysis

Transcranial Magnetic Stimulation

Cellular Imaging of Epilepsy

NEUROPSYCHOLOGICAL EVALUATION

LONG-TERM MONITORING

VOLUME II

SECTION V GENERAL TREATMENT CONSIDERATIONS

Overview:: General Approaches to Treatment

GENERAL CONSIDERATIONS

PRINCIPLES OF DRUG TREATMENT

STRATEGIES FOR PHARMACOTHERAPY

SPECIAL THERAPEUTIC CONSIDERATIONS

ALTERNATIVE APPROACHES

SECTION VI ANTIEPILEPTIC DRUGS

ANTIEPILEPTIC DRUG DEVELOPMENT

ANTIEPILEPTIC DRUGS

SECTION VII SURGICAL THERAPY

CANDIDATE SELECTION

INVASIVE MONITORING TECHNIQUES

FUNCTIONAL MAPPING TECHNIQUES

THERAPEUTIC SURGICAL PROCEDURES

POSTOPERATIVE FOLLOW-UP

SECTION VIII CLINICAL BIOLOGY OF EPILEPSY>/B>

BIORHYTHMS AND THE AUTONOMIC NERVOUS SYSTEM

COMORBIDITY

NEUROENDOCRINOLOGY

VOLUME III

SECTION IX PSYCHIATRIC AND SOCIAL ISSUES

PSYCHIATRIC ISSUES

SOCIAL ISSUES

SECTION X EPILEPSY SYNDROMES

NEONATAL SYNDROMES

SYNDROMES OF INFANCY AND EARLY CHILDHOOD

SYNDROMES OF LATER CHILDHOOD AND ADOLESCENCE

NON AGE-RELATED AND SPECIAL SYNDROMES

DISEASES ASSOCIATED WITH EPILEPSY

SECTION XI DISORDERS THAT CAN BE CONFUSED WITH EPILEPSY

SYSTEMIC DISTURBANCES

NEUROLOGICAL DISTURBANCES

PSYCHIATRIC DISTURBANCES

SECTION XII DELIVERY OF HEALTH CARE AND SOCIOECONOMIC ISSUES

ORGANIZATION OF HEALTH CARE IN DIFFERENT COUNTRIES

SPECIALIZED CENTERS FOR EPILEPSY

COST AND ALLOCATION OF RESOURCES

Subject Index