This text offers a comprehensive yet concise review of neuroscience while discussing all of the relevant clinical information. The review chapters in the first section of the text are in a user-friendly outline format with high-yield information located in margin notes and clinical topics discussed within the outline and in clinical boxes. The second section of the book contains two 50-questions exams in USMLE format. A CD-ROM that accompanies the book contains a full-color art program, 500 board-style questions and answers with rationales for correct answers as well as all incorrect choices, and a quizzing function that gives scores at the end of the exams.
Section 1: Macroscopic Organization: An overview of Nervous System Structure and Function
Chapter I. Anatomy of the Nervous System I. Divisions of the nervous system II. Dissections III. Horizontal images IV. Coronal images V. Sagittal images VI. Spinal cord anatomy
Chapter II. Development of the Nervous System I. Neural tube and derivatives II. Neural crest and derivatives III. Primary vesicles and derivatives IV. Secondary vesicles and derivatives V. Clinical considerations
Chapter III. Meninges I. Layers of the meninges II. Meningeal vasculature III. Clinical considerations
Chapter IV. The Ventricles and Cerebrospinal Fluid I. Components of the ventricular system II. Cerebrospinal fluid (CSF) III. Clinical considerations
Chapter V. Vasculature I. Cerebral blood flow II. Blood-brain barrier (BBB) III. Anterior circulation: internal carotid system IV. Posterior circulation: vertebral-basilar system V. Anastomoses VI. Venous drainage VII. Spinal cord blood supply VIII. Clinical considerations: cerebrovascular accidents
Section 2: Microscopic Organization: The Nervous System at the cellular level
Chapter VI. Neurocytology I. Neurons II. Synapse III. Neuronal cytoskeleton IV. Axonal transport V. Glia VI. Clinical considerations: response to injury
Chapter VII. Neurophysiology I. Passive membrane properties II. Excitable membrane III. Myelination and saltatory conduction IV. Clinical considerations
Chapter VIII. Synaptic interactions I. Electrical synapse II. Chemical synapse III. Clinical considerations
Chapter IX. Neurochemistry I. Classical neurotransmitters II. Peptide neurotransmitters III. Neurotransmitter receptors IV. Clinical considerations
Section 3: Sensory Systems
Chapter X. Discriminative Touch, Vibration and Conscious Proprioception I. Sensory receptors II. Dorsal column-medial lemniscal system - body III. Trigeminal system - head and neck IV. Clinical considerations
Chapter XI. Pain and Temperature I. Sensory receptors II. Anterolateral system - body III. Trigeminal system - head and neck IV. Clinical considerations
Section 4: Motor Control
Chapter XII. Lower Motor Neurons I. Spinal cord anterior horn II. Cranial motor nuclei III. Neuromuscular junction IV. Clinical considerations
Chapter XII. Upper Motor Neurons I. Corticospinal and corticobulbar pathways II. Extrapyramidal pathways III. Clinical considerations
Chapter XIV. Basal Ganglia I. Function II. Anatomy III. Basal ganglia circuits IV. Basal ganglia neurotransmitters V. Clinical considerations
Chapter XV. Cerebellum I. Function II. Cerebellar anatomy related to function III. Cerebellar cortex IV. Deep cerebellar nuclei V. Cerebellar pathways VI. Clinical considerations
Chapter XVI. Reflexes and their Clinical Significance I. Overview II. Deep tendon reflexes - clinical considerations III. Superficial reflexes - clinical considerations IV. Cranial nerve reflexes - clinical considerations
Section 5: Cranial Nerves and the Special Senses
Chapter XVII. Cranial Nerve Overview I. Overview II. Emergence of cranial nerves III. Locations of cranial nerve nuclei IV. General sensory input V. Motor control VI. Testing cranial nerves
Chapter XVIII. Visual System I. The eye II. Visual processing within the retina III. The visual pathway from the retina to the primary visual cortex
Chapter XIX. Auditory System I. What is Sound? II. Anatomy of the Transduction Apparatus III. Mechanisms underlying sound transduction IV. Auditory Neural Pathway V. Clinical Considerations
Chapter XX. Vestibular System I. Vestibular system receptors II. Pathways within the Vestibular System III. Vestibular Reflexes and Tests of the Vestibular System IV. Clinical Considerations
Chapter XXI. Chemical Senses I. Olfactory system II. Gustatory system III. Clinical considerations
Section 6: Higher Functions of the Brain
Chapter XXII. Homeostasis: The hypothalamus and the autonomic nervous system I. Hypothalamic Anatomy II. Function of the Hypothalamus III. Components of the Autonomic Nervous System IV. ANS Neurotransmitters V. ANS Receptors and Pharmacology VI. ANS Targets VII. Central Autonomic Centers VIII. Clinical Considerations
Chapter XXIII. Sleep, Arousal and the Reticular Activating System I. Reticular system anatomy II. Reticular system function III. Reticular system neurochemistry IV. Assessment of consciousness V. Physiology of sleep VI. Sleep - types VII. Clinical considerations
Chapter XXIV. Learning, Memory and Emotion I. Neural basis of emotion II. Limbic system function III. Limbic system components IV. Substrates for memory V. Clinical considerations
Chapter XXV. The Brain in transition: from infancy to old age I. Brain aging - gross II. Brain aging - histological and physiological III. Functional changes IV. Clinical considerations
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