Kidney disease affects approximately ten percent of the population worldwide, with more than 2.6 million individuals estimated to be receiving renal replacement therapy. Chronic kidney disease (CKD) is fast becoming a major public health issue, with increasing incidence and death rates throughout the world. Many strategies have been proposed to reduce the growing burden of kidney disease; but while early identification and improved access to renal replacement therapies andtransplantation are important, they are unlikely to solve this enormous problem. Efforts focused on primary prevention, protection, and slowing the progression of kidney disease are needed as well. Renal protection is a vital and critical component of protecting the kidneys, promoting recovery, andpreventing further renal loss, yet observational data suggests that awareness of renal protection remains low and the concept of renal protection under-recognized.. Kidney Protection:: Strategies for Renal Preservation is a clinically focused review that aims to address this awareness and knowledge gap. It assembles clinically pertinent information in a concise and lucid format with the goal of helping the clinician protect the kidneys, whether in the ICU, perioperative, or out-patient setting. The authors interdisciplinary approach is inclusive of nephrology, urology, critical care, anesthesia, and emergency medicine. Chapters reviewunderstanding kidney disease, general concepts in protecting renal function, patient selection, assessment, pharmacologic issues, and kidney protection in systemic illness. The latest evidence-based practical guidelines for optimal renal outcomes are also included.
I. Understanding Kidney Disease; 1. Epidemiology and Etiology of Kidney disease; Cecile Couchoud; Sahar Bayat; 2. Pathogenesis of Acute Kidney Injury; David Basile; Babu Padanilam; 3. Adaptations in Acute Kidney Injury: Progression to Chronic Kidney Disease; Navin Jaipaul; 4. Risk factors for Chronic Kidney Disease; Hania Kassem; Bernard jaar; 5. Senescence of the Kidney; Eoin D. OSullivan; David Ferenbach; 6. The kidney in Pregnancy; Samuel Mon-Wei Yu; Anjali Acharya; II. Assessment of Kidney Disease; 7. Laboratory Investigation of the Kidney; Timothy Larson; 8. Imaging of the Kidney; David C. Wymer; 9. Fundamentals of Kidney Pathology; Serena Maria Bagnasco; III. General Concepts in Protecting Kidney Function; 10. Pharmacologic renal protection; Wael Hussein; Austin Stack; 11. Evaluation and Management of Acute Kidney Injury; Bhagwan Dass; William Hahn; Rajesh Mohandas; 12. Slowing progression of Chronic Kidney Disease; Martine Pollack-Zollman; Joseph Vassalotti; 13. Renal Artery Stenosis and Revascularization; Joseph Messana; Raymond R. Townsend; 14. Environmental toxins and the Kidney; Joshua King; Bernard Jaar; 15. Peri-operative Renal Protection; Sapna Shah; Vijay Lapsia; 16. Renal protection in Critically Ill patients; Ryan W. Haines; John R. Prowle; 17. Obstructive Uropathies Priya Deshpande; Suchita Sharma; 18. Nephron Sparing Surgery; Stefano Puliatti; Nancy Ferrari; Bernardo Rocco; Giampaolo Bianchi; Salvatore Micali; 19. Choice of Renal Replacement Therapy; Sara Samoni; Claudio Ronco; 20. Preserving Residual Renal Function; Miten G. Dhruve; Joanne Bargman; IV. Drugs and Kidney Function; 21. Principles of Drug Therapy in Reduced Kidney Function; Tim Nguyen; Tran Tran; Thomas Dowling; 22. Acute Kidney Injury from Therapeutic Agents; Daphne Knicely, Michael J. Choi, Sumeska Thavarajah; 23. Immunological Agents in the Treatment of Glomerulonephritis Samira Farouk; Jonathan Winston; 24. NSAIDs and the Kidney Tonia Kim; Chan, Lili; 25. Contrast and the Kidney; Swapnil Hiremath; 26. Chemotherapeutic agents and the Kidney; Umut Selamet; Ramy M. Hanna; Anjay Rastogi; Ala Abudayyeh; 27. Poisonings & Intoxications; Nikolas Harbord; Muhammed S. Akhter; V. Kidney Protection in systemic illness; 28. Diabetes Mellitus and the Kidney; John He; 29. Hypertension and the Kidney; Rupinder K Sodhi; Marie D. Philipneri; Paul G. Schmitz; 30. Cardiovascular Protection in Chronic Kidney Disease; Jonathan W. Waks; Rulan S. Parekh2, MD,; Larisa G. Tereschenko; 31. Lupus Nephritis; Aisha Shaikh; Kirk Campbell; 32. Thrombotic Microangiopathies; Lewis Kaufman; 33. Systemic Inflammatory Diseases and the Kidney; Manny Trujillo; Duvuru Geetha; 34. The Kidney in patients with Cancer; Ramnika Gumber; Akash Sethi; Jonathan Hogan; 35. Cast Nephropathy in Plasma cell Dyscrasias; Sandhya Manohar; Nelson Leung; 36. Sickle Cell Nephropathy; Katia Lopez Revuelta; Maria Pilar Ricard Andres; 37. Kidney disease in HIV infection and Treatment; Christina Wyatt; 38. Cystic Kidney Diseases; Fouad T Chebib; Vincente Torres; 39. Hepatitis Associated Glomerulonephritis; Julie Belliere,; Stanislas Faguer,; Nassim Kamar; 40. Hepatorenal syndrome; Francois Durand, Claire Francoz, Joseph DiNorcia, Yuri S. Genyk, Mitra K. Nadim; 41. Cardiorenal syndrome; Edward Ross; Uyanga Batnyam; Abdo Asmar; 42. Cardiac surgery and the Kidney; Annette L Mazzone; Jonathan Gleadle; 43. Tubulointerstitial Nephropathies; Abhilash Koratala; Girish Singhania; Ahsan Ejaz; 44. Cholesterol Embolism; Alain Meyrier; VI. Kidney Protection in Transplantation; 45. High-risk Kidney Transplantation; Madhav Menon; Susan Lerner; 46. Recurrence of Primary Glomerular Disease Post Kidney Transplantation; Nada Alachkar; John Manello Dieck;
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