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Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)

9781259644030
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Opis

MASTER MODERN MEDICINE!

Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine

The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms

Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrisons Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

Essential for practice and education, the landmark 20th Edition features::

  • Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrisons. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.
  • State-of-the-art coverage of disease mechanisms:: Harrisons focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrisons summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune systems role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.
  • All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include:: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.
  • Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. 
  • Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.
  • End-of-chapter suggested readings reinforc
Szczegóły produktu
60432
9781259644030
9781259644030

Opis

Rok wydania
2018
Numer wydania
20
Oprawa
twarda
Liczba stron
2064
Wymiary (mm)
226 x 285
Waga (g)
6080
  • CONTRIBUTORS
    PREFACE
    Part 1:: The Profession of Medicine
     
    1 The Practice of Medicine
    The Editors


    2 Promoting Good Health
    Donald M. Lloyd-Jones, Kathleen M. McKibbin


    3 Decision-Making in Clinical Medicine
    Daniel B. Mark, John B. Wong


    4 Screening and Prevention of Disease
    Katrina A. Armstrong, Gary J. Martin


    5 Health Care Systems in Developed Countries
    Richard B. Saltman


    6 The Safety and Quality of Health Care
    David W. Bates


    7 Racial and Ethnic Disparities in Health Care
    Joseph R. Betancourt, Alexander R. Green


    8 Ethical Issues in Clinical Medicine
    Bernard Lo, Christine Grady


    9 Palliative and End-of-Life Care
    Ezekiel J. Emanuel
     
    Part 2:: Cardinal Manifestations and Presentation of Diseases
     
    Section 1:: Pain
     
    10 Pain:: Pathophysiology and Management
    James P. Rathmell, Howard L. Fields


    11 Chest Discomfort
    David A. Morrow


    12 Abdominal Pain
    Danny O. Jacobs


    13 Headache
    Peter J. Goadsby


    14 Back and Neck Pain
    John W. Engstrom
     
    Section 2:: Alterations in Body Temperature
     
    15 Fever
    Charles A. Dinarello, Reuven Porat


    16 Fever and Rash
    Elaine T. Kaye, Kenneth M. Kaye


    17 Fever of Unknown Origin
    Chantal P. Bleeker-Rovers, Jos W. M. van der Meer
     
    Section 3:: Nervous System Dysfunction
     
    18 Syncope
    Roy Freeman


    19 Dizziness and Vertigo
    Mark F. Walker, Robert B. Daroff


    20 Fatigue
    Jeffrey M. Gelfand, Vanja C. Douglas


    21 Neurologic Causes of ?Weakness and Paralysis
    Michael J. Aminoff


    22 Numbness, Tingling, and Sensory Loss
    Michael J. Aminoff


    23 Gait Disorders, Imbalance and Falls
    Jessica M. Baker, Lewis R. Sudarsky


    24 Confusion and Delirium
    S. Andrew Josephson, Bruce L. Miller


    25 Dementia
    William W. Seeley, Bruce L. Miller


    26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral Disorders
    M.-Marsel Mesulam


    27 Sleep Disorders
    Thomas E. Scammell, Clifford B. Saper, Charles A. Czeisler
     
    Section 4:: Disorders of Eyes, Ears, Nose, and Throat
     
    28 Disorders of the Eye
    Jonathan C. Horton


    29 Disorders of Smell and Taste
    Richard L. Doty, Steven M. Bromley


    30 Disorders of Hearing
    Anil K. Lalwani


    31 Sore Throat, Earache, and Upper Respiratory Symptoms
    Michael A. Rubin, Larry C. Ford, Ralph Gonzales


    32 Oral Manifestations of Disease
    Samuel C. Durso
     
    Section 5:: Alterations in Circulatory and Respiratory Functions
     
    33 Dyspnea
    Rebecca M. Baron


    34 Cough 
    Christopher H. Fanta


    35 Hemoptysis
    Anna K. Brady, Patricia A. Kritek


    36 Hypoxia and Cyanosis
    Joseph Loscalzo


    37 Edema
    Eugene Braunwald, Joseph Loscalzo


    38 Approach to the Patient with a Heart Murmur
    Patrick T. OGara, Joseph Loscalzo


    39 Palpitations
    Joseph Loscalzo
     
    Section 6:: Alterations in Gastrointestinal Function
     
    40 Dysphagia
    Ikuo Hirano, Peter J. Kahrilas


    41 Nausea, Vomiting, and Indigestion
    William L. Hasler


    42 Diarrhea and Constipation
    Michael Camilleri, Joseph A. Murray


    43 Unintentional Weight Loss
    J. Larry Jameson


    44 Gastrointestinal Bleeding
    Loren Laine


    45 Jaundice
    Savio John, Daniel S. Pratt


    46 Abdominal Swelling and Ascites
    Kathleen E. Corey, Lawrence S. Friedman
     
    Section 7:: Alterations in Renal and Urinary Tract Function
     
    47 Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain Syndrome
    John W. Warren


    48 Azotemia and Urinary Abnormalities
    David B. Mount


    49 Fluid and Electrolyte Disturbances
    David B. Mount


    50 Hypercalcemia and Hypocalcemia
    Sundeep Khosla


    51 Acidosis and Alkalosis
    Thomas D. DuBose, Jr.
     
    Section 8:: Alterations in the Skin
     
    52 Approach to the Patient with a Skin Disorder
    Kim B. Yancey, Thomas J. Lawley


    53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
    Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley


    54 Skin Manifestations of Internal Disease
    Jean L. Bolognia, Irwin M. Braverman


    55 Immunologically Mediated Skin Diseases
    Kim B. Yancey, Thomas J. Lawley


    56 Cutaneous Drug Reactions
    Robert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai


    57 Photosensitivity and Other Reactions to Light
    Alexander G. Marneros, David R. Bickers
     
    Section 9:: Hematologic Alterations
     
    58 Interpreting Peripheral Blood Smears 
    Dan L. Longo


    59 Anemia and Polycythemia
    John W. Adamson, Dan L. Longo


    60 Disorders of Granulocytes and Monocytes
    Steven M. Holland, John I. Gallin


    61 Bleeding and Thrombosis
    Barbara A. Konkle


    62 Enlargement of Lymph Nodes and Spleen
    Dan L. Longo
     
    Part 3:: Pharmacology
     
    63 Principles of Clinical Pharmacology
    Dan M. Roden


    64 Pharmacogenomics
    Dan M. Roden
     
    Part 4:: Oncology and Hematology
     
    Section 1:: Neoplastic Disorders
     
    65 Approach to the Patient with Cancer
    Dan L. Longo


    66 Prevention and Early Detection of ?Cancer
    Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer


    67 Cancer Genetics
    Fred Bunz, Bert Vogelstein


    68 Cancer Cell Biology
    Jeffrey W. Clark, Dan L. Longo


    69 Principles of Cancer Treatment
    Edward A. Sausville, Dan L. Longo


    70 Infections in Patients with Cancer
    Robert W. Finberg


    71 Oncologic Emergencies
    Rasim Gucalp, Janice P. Dutcher


    72 Cancer of the Skin
    Brendan D. Curti, Sancy Leachman, Walter J. Urba 


    73 Head and Neck Cancer
    Everett E. Vokes


    74 Neoplasms of the Lung
    Leora Horn, Christine M. Lovly


    75 Breast Cancer
    Daniel F. Hayes, Marc E. Lippman


    76 Upper Gastrointestinal Tract Cancers
    Robert J. Mayer


    77 Lower Gastrointestinal Cancers
    Robert J. Mayer


    78 Tumors of the Liver and Biliary Tree
    Josep M. Llovet


    79 Pancreatic Cancer
    Daniel D. Von Hoff


    80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas
    Robert T. Jensen


    81 Renal Cell Carcinoma
    Robert J. Motzer


    82 Cancer of the Bladder and Urinary Tract
    Noah M. Hahn


    83 Benign and Malignant Diseases of the Prostate
    Howard I. Scher, James A. Eastham


    84 Testicular Cancer
    David J. Vaughn


    85 Gynecologic Malignancies
    David Spriggs


    86 Primary and Metastatic Tumors of the Nervous System
    Lisa M. DeAngelis, Patrick Y. Wen


    87 Soft Tissue and Bone Sarcomas and Bone Metastases
    Shreyaskumar R. Patel


    88 Carcinoma of Unknown Primary
    Gauri R. Varadhachary, James L. Abbruzzese


    89 Paraneoplastic Syndromes:: Endocrinologic/Hematologic
    J. Larry Jameson, Dan L. Longo


    90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
    Josep Dalmau, Myrna R. Rosenfeld


    91 Late Consequences of Cancer and Its Treatment
    Carl E. Freter, Dan L. Longo
     
    Section 2:: Hematopoietic Disorders
     
    92 Hematopoietic Stem Cells
    David T. Scadden, Dan L. Longo


    93 Iron Deficiency and Other Hypoproliferative Anemias
    John W. Adamson


    94 Disorders of Hemoglobin
    Edward J. Benz, Jr.


    95 Megaloblastic Anemias
    A. Victor Hoffbrand


    96 Hemolytic Anemias 
    Lucio Luzzatto


    97 Anemia Due to Acute Blood Loss
    Dan L. Longo


    98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
    Neal S. Young


    99 Polycythemia Vera and Other Myeloproliferative Neoplasms
    Jerry L. Spivak


    100 Acute Myeloid Leukemia
    William Blum, Clara D. Bloomfield


    101 Chronic Myeloid Leukemia
    Hagop Kantarjian, Jorge Cortes


    102 Acute Lymphoid Leukemia
    Dieter Hoelzer 


    103 Chronic Lymphocytic Leukemia
    Jennifer A. Woyach, John C. Byrd


    104 Non-Hodgkins Lymphoma
    Caron A. Jacobson, Dan L. Longo


    105 Hodgkins Lymphoma 
    Caron A. Jacobson, Dan L. Longo


    106 Less Common Hematologic Malignancies
    Ayalew Tefferi, Dan L. Longo


    107 Plasma Cell Disorders
    Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson


    108 Amyloidosis
    John L. Berk, Vaishali Sanchorawala 


    109 Transfusion Biology and Therapy
    Jeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson


    110 Hematopoietic Cell Transplantation
    Frederick R. Appelbaum
     
    Section 3:: Disorders of Hemostasis
     
    111 Disorders of Platelets and Vessel Wall
    Barbara A. Konkle


    112 Coagulation Disorders
    Valder R. Arruda, Katherine A. High


    113 Arterial and Venous Thrombosis
    Jane E. Freedman, Joseph Loscalzo


    114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
    Jeffrey I. Weitz
     
    Part 5:: Infectious Diseases
     
    Section 1:: Basic Considerations in Infectious Diseases
     
    115 Approach to the Patient with an Infectious Disease
    Neeraj K. Surana, Dennis L. Kasper


    116 Molecular Mechanisms of Microbial Pathogenesis
    Gerald B. Pier


    117 Approach to the Acutely Ill Infected Febrile Patient
    Tamar F. Barlam, Dennis L. Kasper


    118 Immunization Principles and Vaccine Use
    Nancy Messonnier, Anne Schuchat, Lisa A. Jackson


    119 Health Recommendations for International Travel
    Jay S. Keystone, Phyllis E. Kozarsky


    120 Climate Change and Infectious Disease
    Aaron S. Bernstein
     
    Section 2:: Clinical Syndromes:: Community-Acquired Infections
     
    121 Pneumonia
    Lionel A. Mandell, Richard G. Wunderink


    122 Lung Abscess
    Rebecca M. Baron, Miriam Baron Barshak


    123 Infective Endocarditis
    Adolf W. Karchmer


    124 Infections of the Skin, Muscles, and Soft Tissues
    Dennis L. Stevens


    125 Infectious Arthritis
    Lawrence C. Madoff


    126 Osteomyelitis
    Werner Zimmerli


    127 Intraabdominal Infections and Abscesses
    Miriam Baron Barshak, Dennis L. Kasper


    128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
    Richelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque


    129 Clostridium difficile Infection, Including Pseudomembranous Colitis
    Dale N. Gerding, Stuart Johnson


    130 Urinary Tract Infections, Pyelonephritis, and Prostatitis
    Kalpana Gupta, Barbara W. Trautner


    131 Sexually Transmitted Infections:: Overview and Clinical Approach
    Jeanne M. Marrazzo, King K. Holmes


    132 Encephalitis
    Karen L. Roos, Kenneth L. Tyler


    133 Acute Meningitis
    Karen L. Roos, Kenneth L. Tyler


    134 Chronic and Recurrent Meningitis
    Walter J. Koroshetz, Michael R. Wilson, Avindra Nath


    135 Brain Abscess and Empyema
    Karen L. Roos, Kenneth L. Tyler


    136 Infectious Complications of Bites
    Sandeep S. Jubbal, Florencia Pereyra, Lawrence C. Madoff
     
    Section 3:: Clinical Syndromes:: Health Care-Associated Infections
     
    137 Infections Acquired in Health Care Facilities
    Robert A. Weinstein


    138 Infections in Transplant Recipients
    Robert W. Finberg, Joyce D. Fingeroth
     
    Section 4:: Therapy for Bacterial Diseases
     
    139 Treatment and Prophylaxis of Bacterial Infections
    David C. Hooper, Erica S. Shenoy, Christy A. Varughese


    140 Bacterial Resistance to Antimicrobial Agents
    David C. Hooper
     
    Section 5:: Diseases Caused by Gram-Positive Bacteria
     
    141 Pneumococcal Infections
    David Goldblatt, Katherine L. OBrien


    142 Staphylococcal Infections
    Franklin D. Lowy


    143 Streptococcal Infections
    Michael R. Wessels


    144 Enterococcal Infections
    Cesar A. Arias, Barbara E. Murray


    145 Diphtheria and Other Corynebacterial Infections
    William R. Bishai, John R. Murphy


    146 Listeria monocytogenes Infections
    Elizabeth L. Hohmann, Daniel A. Portnoy


    147 Tetanus
    C. Louise Thwaites, Lam Minh Yen


    148 Botulism
    Agam K. Rao, Susan Maslanka


    149 Gas Gangrene and Other Clostridial Infections
    Amy E. Bryant, Dennis L. Stevens
     
    Section 6:: Diseases Caused by Gram-Negative Bacteria
     
    150 Meningococcal Infections
    Andrew J. Pollard 


    151 Gonococcal Infections
    Sanjay Ram, Peter A. Rice


    152 Haemophilus and Moraxella Infections
    Timothy F. Murphy


    153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
    Tamar F. Barlam, Dennis L. Kasper


    154 Legionella Infections
    Victor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin


    155 Pertussis and Other Bordetella Infections
    Karina A. Top, Scott A. Halperin


    156 Diseases Caused by Gram-Negative Enteric Bacilli
    Thomas A. Russo, James R. Johnson


    157 Acinetobacter Infections
    Rossana Rosa, L. Silvia Munoz-Price


    158 Helicobacter pylori Infections
    John C. Atherton, Martin J. Blaser


    159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species
    Reuben Ramphal


    160 Salmonellosis
    David A. Pegues, Samuel I. Miller


    161 Shigellosis
    Philippe J. Sansonetti, Jean Bergounioux


    162 Infections Due to Campylobacter and Related Organisms
    Beth D. Kirkpatrick, Martin J. Blaser


    163 Cholera and Other Vibrioses
    Matthew K. Waldor, Edward T. Ryan 


    164 Brucellosis
    Nicholas J. Beeching


    165 Tularemia
    Jeannine M. Petersen, Paul S. Mead


    166 Plague and Other Yersinia Infections
    Michael B. Prentice


    167 Bartonella Infections, Including Cat-Scratch Disease
    Michael Giladi, Moshe Ephros


    168 Donovanosis
    Nigel OFarrell
     
    Section 7:: Miscellaneous Bacterial Infections
     
    169 Nocardiosis
    Gregory A. Filice


    170 Actinomycosis 
    Thomas A. Russo


    171 Whipples Disease
    Thomas A. Russo


    172 Infections Due to Mixed Anaerobic Organisms
    Neeraj K. Surana, Dennis L. Kasper
     
    Section 8:: Mycobacterial Diseases
     
    173 Tuberculosis
    Mario C. Raviglione


    174 Leprosy
    Robert H. Gelber


    175 Nontuberculous Mycobacterial Infections
    Steven M. Holland


    176 Antimycobacterial Agents
    Divya Reddy, Max R. ODonnell
     
    Section 9:: Spirochetal Diseases
     
    177 Syphilis
    Sheila A. Lukehart


    178 Endemic Treponematoses
    Sheila A. Lukehart


    179 Leptospirosis
    Jiři F. P. Wagenaar, Marga G. A. Goris


    180 Relapsing Fever
    Alan G. Barbour


    181 Lyme Borreliosis
    Allen C. Steere
     
    Section 10:: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
     
    182 Rickettsial Diseases
    David H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas J. Marrie


    183 Infections Due to Mycoplasmas
    R. Doug Hardy


    184 Chlamydial Infections
    Charlotte A. Gaydos, Thomas C. Quinn
     
    Section 11:: Viral Diseases:: General Considerations
     
    185 Medical Virology
    Fred Wang, Elliott Kieff


    186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs
    Lindsey R. Baden
     
    Section 12:: Infections Due to DNA Viruses
     
    187 Herpes Simplex Virus Infections
    Lawrence Corey


    188 Varicella-Zoster Virus Infections
    Richard J. Whitley


    189 Epstein-Barr Virus Infections, Including Infectious Mononucleosis
    Jeffrey I. Cohen


    190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
    Camille Nelson Kotton, Martin S. Hirsch


    191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections
    Fred Wang


    192 Parvovirus Infections
    Kevin E. Brown


    193 Human Papillomavirus Infections
    Darron R. Brown, Aaron Ermel
     
    Section 13:: Infections Due to DNA and RNA Respiratory Viruses
     
    194 Common Viral Respiratory Infections 
    James E. Crowe, Jr.


    195 Influenza
    Peter F. Wright
     
    Section 14:: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
     
    196 The Human Retroviruses
    Dan L. Longo, Anthony S. Fauci


    197 Human Immunodeficiency Virus Disease:: AIDS and Related Disorders
    Anthony S. Fauci, Gregory K. Folkers, H. Clifford Lane
     
    Section 15:: Infections Due to RNA Viruses
     
    198 Viral Gastroenteritis
    Umesh D. Parashar, Roger I. Glass


    199 Enterovirus, Parechovirus, and Reovirus Infections
    Jeffrey I. Cohen


    200 Measles (Rubeola)
    Kaitlin Rainwater-Lovett, William J. Moss


    201 Rubella (German Measles)
    Laura A. Zimmerman, Susan E. Reef


    202 Mumps
    Steven A. Rubin


    203 Rabies and Other Rhabdovirus Infections
    Alan C. Jackson


    204 Arthropod-Borne and Rodent-Borne Virus Infections
    Jens H. Kuhn, Remi N. Charrel


    205 Ebolavirus and Marburgvirus Infections
    Jens H. Kuhn
     
    Section 16:: Fungal Infections
     
    206 Diagnosis and Treatment of Fungal Infections
    John E. Edwards, Jr. 


    207 Histoplasmosis
    Chadi A. Hage, L. Joseph Wheat


    208 Coccidioidomycosis
    Neil M. Ampel


    209 Blastomycosis
    S. Travis King, Rathel L. Nolan, III 


    210 Cryptococcosis
    Arturo Casadevall


    211 Candidiasis
    John E. Edwards, Jr.


    212 Aspergillosis
    David W. Denning


    213 Mucormycosis
    Brad Spellberg, Ashraf S. Ibrahim


    214 Superficial Mycoses and Less Common Systemic Mycoses
    Carol A. Kauffman


    215 Pneumocystis Infections
    Alison Morris, Henry Masur
     
    Section 17:: Protozoal and Helminthic Infections:: General Considerations
     
    216 Introduction to Parasitic Infections 
    Sharon L. Reed, Charles E. Davis


    217 Agents Used to Treat Parasitic Infections
    Thomas A. Moore
     
    Section 18:: Protozoal Infections
     
    218 Amebiasis and Infection with Free-Living Amebae
    Rosa M. Andrade, Sharon L. Reed


    219 Malaria
    Nicholas J. White, Elizabeth A. Ashley


    220 Babesiosis
    Edouard Vannier, Peter J. Krause


    221 Leishmaniasis
    Shyam Sundar


    222 Chagas Disease and African Trypanosomiasis
    Francois Chappuis, Yves Jackson


    223 Toxoplasma Infections
    Kami Kim


    224 Protozoal Intestinal Infections and Trichomoniasis
    Peter F. Weller
     
    Section 19:: Helminthic Infections
     
    225 Introduction to Helminthic Infections
    Peter F. Weller


    226 Trichinellosis and Other Tissue Nematode Infections
    Peter F. Weller


    227 Intestinal Nematode Infections
    Peter F. Weller, Thomas B. Nutman


    228 Filarial and Related Infections
    Thomas B. Nutman, Peter F. Weller


    229 Schistosomiasis and Other Trematode Infections
    Birgitte Jyding Vennervald


    230 Cestode Infections
    A. Clinton White, Jr., Peter F. Weller
     
    Part 6:: Disorders of the Cardiovascular System
     
    Section 1:: Introduction to Cardiovascular Disorders
     
    231 Approach to the Patient with Possible Cardiovascular Disease
    Joseph Loscalzo


    232 Basic Biology of the Cardiovascular System
    Joseph Loscalzo, Peter Libby, Calum A. MacRae


    233 Epidemiology of Cardiovascular Disease
    Thomas A. Gaziano, J. Michael Gaziano
     
    Section 2:: Diagnosis of Cardiovascular Disorders
     
    234 Physical Examination of the Cardiovascular System
    Patrick T. OGara, Joseph Loscalzo


    235 Electrocardiography
    Ary L. Goldberger


    236 Noninvasive Cardiac Imaging:: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging
    Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 


    237 Diagnostic Cardiac Catheterization and Coronary Angiography
    Jane A. Leopold, David P. Faxon
     
    Section 3:: Disorders of Rhythm
     
    238 Principles of Electrophysiology
    David D. Spragg, Gordon F. Tomaselli


    239 The Bradyarrhythmias:: Disorders of the Sinoatrial Node
    David D. Spragg, Gordon F. Tomaselli


    240 The Bradyarrhythmias:: Disorders of the Atrioventricular Node
    David D. Spragg, Gordon F. Tomaselli


    241 Approach to Supraventricular Tachyarrhythmias
    Gregory F. Michaud, William G. Stevenson


    242 Physiologic and Non-physiologic Sinus Tachycardia 
    Gregory F. Michaud, William G. Stevenson


    243 Focal Atrial Tachycardia 
    Gregory F. Michaud, William G. Stevenson


    244 Paroxysmal Supraventricular Tachycardias
    Gregory F. Michaud, William G. Stevenson


    245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial Tachycardias
    Gregory F. Michaud, William G. Stevenson


    246 Atrial Fibrillation
    Gregory F. Michaud, William G. Stevenson


    247 Approach to Ventricular Arrhythmias 
    Roy M. John, William G. Stevenson


    248 Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm 
    Roy M. John, William G. Stevenson


    249 Sustained Ventricular Tachycardia 
    William G. Stevenson, Roy M. John


    250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
    William G. Stevenson, Roy M. John


    251 Electrical Storm and Incessant VT
    William G. Stevenson, Roy M. John
     
    Section 4:: Disorders of the Heart
     
    252 Heart Failure:: Pathophysiology and Diagnosis
    Douglas L. Mann, Murali Chakinala


    253 Heart Failure:: Management
    Mandeep R. Mehra 


    254 Cardiomyopathy and Myocarditis
    Neal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo


    255 Cardiac Transplantation and Prolonged Assisted Circulation 
    Mandeep R. Mehra


    256 Aortic Valve ?Disease
    Patrick T. OGara, Joseph Loscalzo


    257 Aortic Regurgitation 
    Patrick T. OGara, Joseph Loscalzo


    258 Mitral Stenosis
    Patrick T. OGara, Joseph Loscalzo


    259 Mitral Regurgitation
    Patrick T. OGara, Joseph Loscalzo


    260 Mitral Valve Prolapse
    Patrick T. OGara, Joseph Loscalzo


    261 Tricuspid Valve Disease
    Patrick T. OGara, Joseph Loscalzo


    262 Pulmonic Valve Disease
    Patrick T. OGara, Joseph Loscalzo


    263 Multiple and Mixed Valvular Heart Disease
    Patrick T. OGara, Joseph Loscalzo


    264 Congenital Heart Disease in the Adult
    Anne Marie Valente, Michael J. Landzberg


    265 Pericardial Disease
    Eugene Braunwald


    266 Atrial Myxoma and Other Cardiac Tumors
    Eric H. Awtry
     
    Section 5:: Coronary and Peripheral Vascular Disease
     
    267 Ischemic Heart Disease
    Elliott Antman, Joseph Loscalzo


    268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
    Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald


    269 ST-Segment Elevation Myocardial Infarction
    Elliott M. Antman, Joseph Loscalzo


    270 Percutaneous Coronary Interventions and Other Interventional Procedures
    David P. Faxon, Deepak L. Bhatt


    271 Hypertensive Vascular Disease
    Theodore A. Kotchen


    272 Renovascular Disease
    Stephen C. Textor


    273 Deep Venous Thrombosis and Pulmonary Thromboembolism
    Samuel Z. Goldhaber


    274 Diseases of the Aorta
    Mark A. Creager, Joseph Loscalzo


    275 Arterial Diseases of the Extremities
    Mark A. Creager, Joseph Loscalzo


    276 Chronic Venous Disease and Lymphedema 
    Mark A. Creager, Joseph Loscalzo


    277 Pulmonary Hypertension
    Aaron B. Waxman, Joseph Loscalzo
     
    Part 7:: Disorders of the Respiratory System
     
    Section 1:: Diagnosis of Respiratory Disorders
     
    278 Approach to the Patient with Disease of the Respiratory System
    Patricia A. Kritek, Bruce D. Levy


    279 Disturbances of Respiratory Function
    Edward T. Naureckas, Julian Solway 


    280 Diagnostic Procedures in Respiratory Disease
    Anne L. Fuhlbrigge, Augustine M.K. Choi 
     
    Section 2:: Diseases of the Respiratory System
     
    281 Asthma
    Peter J. Barnes


    282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
    Praveen Akuthota, Michael E. Wechsler


    283 Occupational and Environmental Lung Disease
    John R. Balmes


    284 Bronchiectasis
    Rebecca M. Baron, Miriam Baron Barshak


    285 Cystic Fibrosis
    Eric J. Sorscher


    286 Chronic Obstructive Pulmonary Disease
    Edwin K. Silverman, James D. Crapo, Barry Make


    287 Interstitial Lung Disease
    Gary M. Hunninghake, Ivan O. Rosas


    288 Disorders of the Pleura
    Richard W. Light


    289 Disorders of the Mediastinum
    Richard W. Light


    290 Disorders of Ventilation 
    John F. McConville, Julian Solway, Babak Mokhlesi 


    291 Sleep Apnea
    Andrew Wellman, Susan Redline


    292 Lung Transplantation
    Elbert P. Trulock, III
     
    Part 8:: Critical Care Medicine
     
    Section 1:: Respiratory Critical Care
     
    293 Approach to the Patient with Critical Illness
    John P. Kress, Jesse B. Hall


    294 Acute Respiratory Distress Syndrome
    Rebecca M. Baron, Bruce D. Levy


    295 Mechanical Ventilatory Support
    Bartolome R. Celli
     
    Section 2:: Shock and Cardiac Arrest
     
    296 Approach to the Patient with Shock
    Anthony F. Massaro


    297 Sepsis and Septic Shock
    Christopher W. Seymour, Derek C. Angus


    298 Cardiogenic Shock and Pulmonary Edema
    David H. Ingbar, Holger Thiele


    299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death 
    Christine M. Albert, William G. Stevenson 
     
    Section 3:: Neurologic Critical Care
     
    300 Coma
    S. Andrew Josephson, Allan H. Ropper, Stephen L. Hauser 


    301 Severe Acute Encephalopathies and Critical Care Weakness
    J. Claude Hemphill, III, Wade S. Smith, S. Andrew Josephson, Daryl R. Gress


    302 Subarachnoid Hemorrhage
    J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress
     
    Part 9:: Disorders of the Kidney and Urinary Tract
     
    303 Cellular and Molecular Biology of the Kidney
    Alfred L. George, Jr., Eric G. Neilson


    304 Acute Kidney Injury
    Sushrut S. Waikar, Joseph V. Bonventre


    305 Chronic Kidney Disease 
    Joanne M. Bargman, Karl L. Skorecki


    306 Dialysis in the Treatment of Renal Failure
    Kathleen D. Liu, Glenn M. Chertow


    307 Transplantation in the Treatment of Renal Failure
    Jamil Azzi, Edgar L. Milford, Mohamed H. Sayegh, Anil Chandraker 


    308 Glomerular Diseases
    Julia B. Lewis, Eric G. Neilson


    309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
    Jing Zhou, Martin R.  Pollak


    310 Tubulointerstitial Diseases of the Kidney
    Laurence H. Beck, Jr., David J. Salant


    311 Vascular Injury to the Kidney
    Ronald S. Go, Nelson Leung


    312 Nephrolithiasis
    Gary C. Curhan


    313 Urinary Tract Obstruction
    Julian L. Seifter
     
    Part 10:: Disorders of the Gastrointestinal System
     
    Section 1:: Disorders of the Alimentary Tract
     
    314 Approach to the Patient with Gastrointestinal Disease
    William L. Hasler, Chung Owyang


    315 Gastrointestinal Endoscopy
    Louis Michel Wong Kee Song, Mark Topazian


    316 Diseases of the Esophagus
    Peter J. Kahrilas, Ikuo Hirano


    317 Peptic Ulcer Disease and Related Disorders
    John Del Valle


    318 Disorders of Absorption
    Henry J. Binder


    319 Inflammatory Bowel Disease
    Sonia Friedman, Richard S. Blumberg


    320 Irritable Bowel Syndrome
    Chung Owyang


    321 Diverticular Disease and Common Anorectal Disorders
    Rizwan Ahmed, Susan L. Gearhart


    322 Mesenteric Vascular Insufficiency
    Satinderjit Locham, Mahmoud Malas


    323 Acute Intestinal Obstruction
    Danny O. Jacobs


    324 Acute Appendicitis and Peritonitis
    Danny O. Jacobs
     
    Section 2:: Nutrition 
     
    325 Nutrient Requirements and Dietary Assessment
    Johanna Dwyer


    326 Vitamin and Trace Mineral Deficiency and Excess
    Paolo M. Suter, Robert M. Russell


    327 Malnutrition and Nutritional Assessment 
    Gordon L. Jensen


    328 Enteral and Parenteral Nutrition
    L. John Hoffer, Bruce R. Bistrian, David F. Driscoll
     
    Section 3:: Liver and Biliary Tract Disease
     
    329 Approach to the Patient with Liver Disease
    Marc G. Ghany, Jay H. Hoofnagle 


    330 Evaluation of Liver Function
    Daniel S. Pratt


    331 The Hyperbilirubinemias
    Allan W. Wolkoff


    332 Acute Viral Hepatitis
    Jules L. Dienstag


    333 Toxic and Drug-Induced Hepatitis
    William M. Lee, Jules L. Dienstag


    334 Chronic Hepatitis
    Jules L. Dienstag


    335 Alcoholic Liver Disease
    Mark E. Mailliard, Michael F. Sorrell


    336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis
    Manal F. Abdelmalek, Anna Mae Diehl


    337 Cirrhosis and Its Complications
    Bruce R. Bacon


    338 Liver Transplantation
    Raymond T. Chung, Jules L. Dienstag


    339 Diseases of the Gallbladder and Bile Ducts
    Norton J. Greenberger, Gustav Paumgartner
     
    Section 4:: Disorders of the Pancreas
     
    340 Approach to the Patient with Pancreatic Disease
    Darwin L. Conwell, Norton J. Greenberger, Peter A. Banks


    341 Acute and Chronic Pancreatitis
    Darwin L. Co
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