There are unique psychological hazards to all critical care therapies and this new issue of Critical Care Clinics explores them. With content tailored to mirror the specific psychiatric issues that normally arise in the critical care setting, Guest Editor Jose Maldonado has selected topics and authors at the forefront of this topic. Issues such as Neuropsychiatric Consequences of Trauma & Head Injury, Delirium:: Pathophysiology, Diagnosis & Treatment, Anxiety Disorders & the Outcomes of Trauma, and Psychiatric & Palliative Care in the ICU are explored.