In this issue of Infectious Disease Clinics of North America, guest editor Dr. Laura Certain brings her considerable expertise to the topic of Musculoskeletal Infections. Top experts present current data on how best to diagnose and manage diabetic foot infections, periprosthetic joint infections, vertebral osteomyelitis, infection after fracture fixation, and more. Notably, in many cases the optimal treatment approach remains unclear; in those cases, authors present what data is available, and how experts in orthopedic infections typically proceed. In addition, surgical colleagues provide a brief overview of considerations for surgical management of these infections.