This book provides an up-to-date and thorough introduction to general pathology. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated for this Second Edition, to present a current but deep understanding of disease states at the cell and tissue levels. It includes major sectionson cellular pathology, inflammation, immunopathology, vascular disturbance, and tumour biology.
Introduction; Part I: Cellular Pathology; The long road to the elementary patient; Cellular adaptations; Symptoms of cellular disease: Intracellular accumulations; Pathology of the organelles; Cell injury and cell death; Pathologic calcification; Extracellular pathology; Part II: Inflammation; Introduction to inflammation; Inflammation: The actors and their language; The four cardinal signs of inflammation; Leukocytes called to action: Steps to Phagocytosis; The inflammatory exudate; Chronic inflammation; Wound healing; General effects of local injury and inflammation; Variations and aberrations of the inflammatory response; Part III: Immunopathology; Hypersensitivity reactions; Pathology of transplantation; Autoimmune disease; Immunosuppression; Part IV: Vascular Disturbances; Disturbances of fluid exchange; Hemostasis and thrombosis; Obstacles to blood flow; Ischemia and shock; Part V: Tumors; Tumors: Names and personalities; Anatomy and biology of tumors; Tumor aggression; The causes of tumors; Genes and tumors; Antitumor defences; The reversibility of tumors; Epidemiology of human cancer; What is a tumor?; Tumors as a clinical problem;
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