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Ketogenic Diet and Metabolic Therapies

Ketogenic Diet and Metabolic Therapies

Expanded Roles in Health and Disease

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Ketogenic diets have treated epilepsy for nearly 100 years, yet metabolic therapy has remained obscure and underutilized for most of this time. In recent decades, the clinical efficacy of ketogenic therapy was confirmed definitively for pediatric epilepsy and has now expanded to adult epilepsy. Now, the benefits of metabolic therapy have been extended well beyond epilepsy to additional neurological, metabolic, and genetic disorders, and the importance of metabolic health isrecognized as paramount. This new edition of Ketogenic Diet and Metabolic Therapies:: Expanded Roles in Health and Disease highlights the growing research and clinical applications of metabolic therapies as effective in disease treatment, reversal and prevention. Emerging mechanisms include the landscape of the microbiome and epigenetics. Consistent with the first observations in 1921, in some cases metabolism-based strategies have proven equal or superior to pharmacological treatments for specific diseases andfor treating multiple comorbidities. This second edition commemorates the 100th anniversary of the ketogenic diet, shares new research in this rapidly moving field, and offers a valuable collection of high-resolution color figures. The team of editors for this edition have been working in this area for decades, and in this volume, they have assembled world leaders in this cutting-edge research. As the first academic, interdisciplinary book on ketogenic diet and metabolic therapy, this volume will be crucial during this time ofincreased appreciation for metabolic health in professionals and the public alike.
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Numer wydania
miękka foliowana
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178 x 254
  • 1. General overview/introduction by co-editors, with a historical perspective; Section I. Ketogenic Diet for Epilepsy in the Clinic; 2. Overview:: Ketogenic Diets and Pediatric Epilepsy:: An Update; 3. Alternative Ketogenic Diets; 4. Ketogenic Diet Therapies in Adults:: History, Demand, and Results; 5. How Do You Implement the Diet?; 6. Glut1 Deficiency Syndrome and the Ketogenic Dietary Therapies; 7. Ketogenic Diet in Established Epilepsy Indications; 8. Ketogenic Diet for Other Epilepsies; 9. The Ketogenic Diets in Idiopathic Generalized Epilepsy Syndromes; 10. Ketogenic Diet Therapy for Infants with Pharmacoresistant Epilepsy and/or Metabolic Disease; 11. Ketogenic Diet in Status Epilepticus; 12. Preventing Side Effects and Diet Discontinuation; Section II. Ketogenic Diet:: Emerging Clinical Applications and Future Potential; 13. Overview:: Expanded Uses of Ketogenic Therapies; 14. Metabolism-Based Treatments for Managing Cancer:: Scientific Rationale; 15. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer; 16. Ketogenic Diet, Social Behavior, and Autism:: Insights from Animal Models; 17. Ketotherapeutics to Rescue Brain Energy Deficits:: An Emerging Strategy to Delay Cognitive Decline in Alzheimers Disease; 18. Ketogenic Diet and Ketones for Improving Neurological Outcomes after Acute Neurotrauma; 19. Ketogenic Diets and Neuroinflammation; 20. The Ketogenic Diet in the Treatment of Schizophrenia; 21. The Ketogenic Diet and the Gut Microbiome; Section III. Ketogenic Diet in the Laboratory; 22. Overview of Ketogenic Diet in the Laboratory:: Progress on Models and Mechanisms; 23. Ketogenic Diet and PPARy; 24. Ketogenic Diet and Adenosine in Epilepsy - Models and Mechanisms; 25. Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis; 26. Ketogenic Diet, Aging, and Neurodegeneration; 27. Metabolic Seizure Resistance via BAD and KATP Channels; 28. Lactate Dehydrogenase:: a Novel Metabolic Target; 29. Effects of the Ketogenic Diet on the Blood-Brain Barrier; 30. Metabolic and Redox Alterations by Ketogenic Diets; 31. Nicotinamide Adenine Dinucleotide as a Central Mediator of the Ketogenic therapy; Section IV. Ketone-Based Metabolism:: General Health and Metabolic Alternatives; 32. Overview of Ketone-Based Metabolism:: General Health and Metabolic Alternatives; 33. Ketone Supplementation for Health and Disease; 34. Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-evoked Ketosis; 35. Amino Acids in the Treatment of Neurological Disorders; 36. Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet; 37. Triheptanoin in Epilepsy and Beyond; 38. Anti-seizure and Anti-epileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose; 39. Low Carbohydrate, Ketogenic Diets for the Treatment of Type 2 Diabetes and Obesity; 40. Intermittent Exogenous Ketosis for Athletic Performance, Recovery and Adaptation; 41. Advancing the Awareness and Application of Metabolic and Ketogenic Therapies Globally and Offering Hope;
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