Natural vitamin E includes two groups of closely related fat-soluble compounds, tocopherols and tocotrienols, each composed of four isoforms. α-Tocopherol is a very well-known potent antioxidant and radical scavenger in chemical and biological systems. Its structure has served as template for design and synthesis of more potent antioxidant analogues with regard to its potential protective effect against certain diseases associated with ageing -- particularly cancer and heart disease. This book presents and discusses current research in the study of tocopherols. Topics discussed include quantification, antioxidant activity and pro-oxidant effects of α-tocopherols from several sources, design, synthesis and biological activity of tocopherol based hybrid molecules. Chromatographic separation of tocopherol isomers.
Preface; Virgin olive oil (voo) & other olive tree products as sources of α-tocopherol. Updating & perspective; Quantification & antioxidant activity of α-tocopherols from some tunisian olive oil; Visualization of α-tocopherol in biological samples using imaging mass spectrometry; Design, synthesis, & biological activity of new derivatives & hybrid analogs; Chromatographic separation of tocopherol isomers; The antioxidant role of tocopherol in food packaging; Interaction between light quality & tocopherol antioxidant activity; Pro-oxidant effects of vitamin E; Functionality of tocopherol isomers; Vitamin E & adipose tissue physiology; Tocopherol:: uses male in reproduction; Effect of tocopherol on the ischemia-reperfusion injury of the brain; Metabolism & function of vitamin E; Regulation of neutorophil functions & signaling by vitamin E compounds; Synthetic tocopherol analogues:: role & therapeutics implications in aging diseases; Neurodegeneration through oxidative stress & aging, & its prevention by vitamin E; The possible role of vitamin E in depressive disorders; Index.
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