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Developmental Origins of Health and Disease

Developmental Origins of Health and Disease

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The concept of the early life developmental origins of health and disease (DOHaD) in adults has stimulated a new approach to understanding disease trajectories, with major public health implications. Indeed, the principle of the lifecourse of disease now influences health policies internationally. Environmental influences during pregnancy and early life that affect lifelong health are well documented, but there is a new focus on the preconception period and the significance of paternal health on the fetus. This fully revised second edition highlights scientific and clinical advances in the field, exploring new understanding of mechanisms such as epigenetics and the increasingly recognised role of external influences, including pollution. The book is structured logically, covering environment, clinical outcomes, mechanisms of DOHaD, interventions throughout the lifespan and finally implications for public health and policy. Clinicians and scientists alike will improve their understanding of the developmental origins of health and disease with this essential text.
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  • Section I. Overview: 1. Overview and introduction to the 2nd edition of the developmental origins of health and disease (DOHaD) Lucilla Poston, Keith M. Godfrey, Sir Peter D. Gluckman and Mark A. Hanson; Section II. Exposures driving long-term DOHaD effects: 2. The evolutionary basis of DOHaD Felicia M Low, Peter D Gluckman and Mark A Hanson; 3. Timing: Critical DOHaD windows with lifelong effects Keith M. Godfrey, Tom Fleming, Mary Barker, Judith Stephenson, Mark Vickers, Frank Bloomfield and Rachael Taylor; 4. Long-term effects of food insecurity and undernutrition in early life Sophie E. Moore; 5. Short and long-term effects of maternal obesity and dysglycaemia for women and their children Jodie M. Dodd, Amanda J Poprzeczny, Andrea R. Duessen and Jennie Louise; 6. Long-term DOHaD effects of prenatal maternal stress and mental health Matthias Schwab and Florian Rakers; 7. Environmental exposures in early life: effects of air pollution, chemicals and climate change on human health and wellbeing Kirsten R. Poore, Marie Pedersen and Sibylle Ermler; 8. Developmental programming and the microbiome: How the maternal environment and early life shapes the infant gut microbiome pathway(s) and risk of disease Kameron Y. Sugino and Jacob E. Friedman; 9. Exposures driving long-term effects of DOHaD effects: Influence of assisted reproductive technologies Daniel R. Brison, John C. M. Dumoulin, Hannah L. Morgan, Tessa J. Roseboom and Adam J. Watkins; Section III. Outcomes: 10. Cardiometabolic and renal DOHaD outcomes in offspring of complicated pregnancy Dino A. Giussani, Rebecca M. Reynolds, Paul Leeson, Karen M. Moritz, John F. Bertram and Susan E. Ozanne; 11. Development origins of chronic respiratory diseases Liesbeth Duijts, Annemiek Mian, Tarik Karramass and Vincent W. V. Jaddoe; 12. Early life adversity and female reproductive outcomes: How growth, diet and nutrition impact reproductive function and accelerated reproductive ageing Patrycja A. Jazwiec and Deborah M. Sloboda; 13. Developmental programming of ageing induced by poor maternal nutrition; evidence from rodent studies Elena Zambrano and Peter W. Nathanielsz; Section IV. Mechanisms: 14. Visualizing structural underpinnings of DOHaD Kent L. Thornburg, John Bertram, Jacob E. Friedman, David Hill, Kevin Kolahi and Christopher Kroenke; 15. Molecular and epigenetic mechanisms of DOHaD Richard Saffery, Amanda Vlahos and Toby Mansell; 16. The role of the placenta in DOHaD Rohan M. Lewis and Amanda N. Sferruzzi-Perri; Section V. Interventions: 17. Interventions to prevent DOHaD effects in pregnancy Lucilla Poston; 18. Interventions to prevent DOHaD effects in infancy and early childhood Bartłomiej Mateusz Zalewski, Bernadeta Patro-Gołąb, Barbara Bożek, M. Kołodziej, Kathryn V. Dalrymple, Lucilla Poston and Hania Szajewska; Section VI. Public health and policy implications of interventions; 19. Education and science communication: Translation of DOHaD evidence for health benefit Jacquie L. Bay and Suzanne Trask; 20. DOHaD - engaging with new global issues to inform policy Peter D. Gluckman and Mark A. Hanson.
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