Estradiol: Synthesis, Functions & Effectiveness

Oestrogens comprise a group of structurally related and hormonally active molecules derived from cholesterol. 17β-estradiol (E2) is the most potent member of this group. In Chapter One, the authors summarize various aspects of oestradiol signalling, with special emphasis in the fast action of the hormone. Chapter Two discusses oestradiol signalling pathways and how deficiency of oestrogen, in the postmenopausal period, would cause CVS diseases and the potential therapeutic effect of oestrogen for preventing cardiovascular diseases in postmenopausal women. Chapter Three covers a project that was undertaken to obtain an unbiased survey of differential gene expression in the liver in response to oestrogen, TAM, and RAL.