This book reviews research on presently known theories and mechanisms responsible for the rate of ageing and maximum longevity of different animals including birds, mammals and humans (to explain how do we age and the velocity of the ageing process). In addition, this book deals with the historical evolutionary explanations of ageing and longevity (why do we age). The mechanisms discussed include mitochondria and oxygen free radicals, the presence of macromolecules constitutively highly resistant to deleterious modification in the tissues of long-lived animals, insulin/IGF-1 like signalling, telomere shortening, dietary restrictions, and other proposed molecular mechanisms.
Foreword; Introduction; Aging, Longevity & Disease:: From Ephemeral Life to Eternal Youth; What Causes Aging?:: Theories of Biological Aging; The Double Edge Sword:: Oxygen as Needed for Life & as a Main Cause of Aging; Eating Less Prolongs Life; Only Change is Eternal:: Mechanisms of Biological Evolution; Why Aging?:: Evolutionary Explanations of Longevity; The States of the Evolution of Complexity; Glossary; References; Index.
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