Stem cells are the building blocks of the body. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and auto-immune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Therefore, stem cell research is as important for our understanding the physio- and pathology of the body, as it is for understanding of development and therapy, including for the nervous system. This book provides an overview and in-depth analysis of recent developments in stem cell research and therapy.
Introduction -- Adult neural stem cells from promise to treatment:: the road ahead; Adult neurogenesis in mammals; Protocols for studying adult neurogenesis:: insights & recent developments; Adult neural stem cells, neurogenic niches & cellular therapy; The therapeutic potential of adult neural stem cells; Human neural progenitor & stem cells; Adult neurogenesis pharmacology in neurological diseases & disorders; Characterization & isolation of synapses of newly generated neuronal cells of the adult hippocampus at early stages of neurogenesis; Adult neurogenesis & neural stem cells as a model for the discovery & development of novel drugs; Neurogenic drugs & compounds; Magnetic resonance imaging for monitoring neurogenesis in the adult hippocampus; Transplantation of cord blood stem cells for treating hematologic diseases:: strategies to improve engraftment; Transplantation of two populations of stem cells to improve engraftment; ADA-transduced hematopoietic stem cell therapy for ADA-SCID; Adult periodontal-derived neural progenitor & stem cells; Conclusion (1). Stem cells from non-viable versus post-mortem tissues; Conclusion 1. Stem Cells from Non-Viable Versus Post-Mortem Tissues; Conclusion (2). Ex vivo fucosylation to improve the engraftment capability & therapeutic potential of human cord blood stem cells; Index.
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