In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Aasma Shaukat brings her considerable expertise to the topic of Colorectal Cancer Screening. Top experts provide a comprehensive exploration of evolving CRC risk factors, the latest advancements in non-invasive screening, the role of high-quality colonoscopy in detection and prevention, novel blood-based tests, and the use of AI assistance to improve patient outcomes in this rapidly evolving landscape.