Hematopathology

• I. INHERITED RED CELL DISORDERS

  A. Thalassemias

  Alpha-Thalassemia

  Beta-Thalassemia

  B. Hemoglobinopathies

  Sickle Cell Disease

  Hemoglobin C Disease

  Hemoglobin E Disease

  Heinz Body Hemolytic Anemia

  C. Enzyme Defects

  Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency

  Pyruvate Kinase Deficiency

  D. Disorders of Heme Synthesis

  Sideroblastic Anemia (Congenital and Acquired)

  E. Red Cell Membrane Disorders

  Hereditary Spherocytosis

  Hereditary Elliptocytosis (HE) and Related Disorders

  F. Other Congenital Red Cell Disorders

  Congenital Dyserythropoietic Anemia (CDA)

  II. ACQUIRED RED CELL DISORDERS

  A. Red Cell Membrane Disorders

  Paroxysmal Nocturnal Hemoglobinuria (PNH)

  B. Nutritional Deficiencies

  Iron Deficiency Anemia (IDA)

  Folate and B₁₂ (Cobalamin) Deficiency

  C. Toxins

  Lead Toxicity

  Hematologic Complications of Alcoholism

  D. Intravascular Hemolysis

  Traumatic Hemolysis

  E. Immunologic Destruction

  Autoimmune Hemolytic Anemia (AIHA)

  F. Myelophthisic Anemias

  Metastatic Lesions in Bone Marrow Biopsies

  Gaucher Disease

  Storage Disorders: Niemann-Pick Disease (NPD)

  G. Red Cell Aplasias

  Red Cell Aplasia

  Parvovirus Infection

  III. INHERITED WHITE CELL AND PLATELET DISORDERS

  Chediak-Higashi Syndrome

  Gray Platelet Syndrome

  May-Hegglin Anomaly

  Pelger-Huet Anomaly

  IV. INFECTIOUS DISORDERS SEEN IN BLOOD

  Malaria

  Babesiosis

  Ehrlichiosis/Anaplasmosis

  African Trypanosomiasis

  Chagas Disease

  V. DISORDERS OF HEMOSTASIS

  Disseminated Intravascular Coagulation (DIC)

  Thrombotic Thrombocytopenia Purpura (TTP)/Hemolytic Uremic Syndrome (HUS)

  VI. BONE MARROW FAILURE SYNDROMES

  Aplastic Anemia

  VII. REACTIVE LYMPHADENOPATHIES

  A. Infections

  Tuberculosis and Mycobacterial Lymphadenopathy

  Cryptococcus Lymphadenitis

  Histoplasmosis

  Candidiasis

  Infectious Mononucleosis

  Cytomegalovirus (CMV) Infection

  Herpes Simplex Virus (HSV) Lymphadenitis

  Toxoplasmosis

  Syphilitic Lymphadenitis

  B. Non-Infectious

  Sarcoidosis

  Systemic Lupus Erythematosus (SLE) Lymphadenopathy

  Rheumatoid Lymphadenopathy

  Castleman Disease

  a. Hyaline Vascular Variant

  b. Multicentric/Plasma Cell Variant

  Foreign Body Lymphadenopathy

  Dermatopathic Lymphadenopathy

  Non-Specific Lymphadenopathy

  VIII. REACTIVE HISTIOCYTIC DISORDERS

  Rosai-Dorfman Disease

  Erdheim-Chester Disease

  Hemophagocytic Lymphohistiocytosis (Primary and Acquired)

  IX. LYMPHOID NEOPLASMS

  A. Lymphoblastic Neoplasms

  B Lymphoblastic Leukemia/Lymphoma (B-ALL/LBL)

  T Lymphoblastic Leukemia/Lymphoma (T-ALL/LBL)

  B. Mature B-Cell Neoplasms

  Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  B-Cell Prolymphocytic Leukemia

  Hairy Cell Leukemia

  Hairy Cell Leukemia---Variant

  Splenic Marginal Zone Lymphoma

  Extranodal Marginal Zone Lymphoma

  A. Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)

  B. Cutaneous Marginal Zone Lymphoma

  Nodal Marginal Zone Lymphoma

  Lymphoplasmacytic Lymphoma

  Mantle Cell Lymphoma

  Follicular Lymphoma

  Primary Cutaneous Follicle Center Lymphoma

  Burkitt Lymphoma (BL)

  Diffuse Large B-Cell Lymphoma (DLBCL), Not Otherwise Specified (Including with Chronic Inflammation)

  B-Cell Lymphoma, Unclassifiable, With Features Intermediate between Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma

  T-Cell/Histiocytic-Rich Large B-Cell Lymphoma

  B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma (CHL)

  Primary Diffuse Large B-Cell Lymphoma (DLBCL) of the CNS

  Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type

  EBV-Positive Diffuse Laarge B-Cell Lymphoma (DLBCL) in the Elderly

  Lymphomatoid Granulomatosis

  Primary Mediastinal Large B-Cell Lymphoma (PMBCL)

  Intravascular Lymphoma

  Plasmablastic Lymphoma

  Large B-Cell Lymphoma Arising in HHV-8-Associated Multicentric Castleman Disease (MCD)

  Primary Effusion Lymphoma and Related Entities

  ALK⁺ Large B-Cell Lymphoma

  C. Plasma Cell Neoplasms

  Monoclonal Gammopathy of Undetermined Significance

  Plasma Cell Myeloma

  Plasmacytoma

  Immunoglobulin Deposition Diseases

  Osteosclerotic Myeloma

  D. Mature T-Cell and NK-Cell Neoplasms

  Mycosis Fungoides

  Sézary Syndrome

  Primary Cutaneous CD30⁺ T-Cell Lymphoproliferative Disorders

• Lymphomatoid Papulosis (LYP)

Primary Cutaneous Gamma-Delta T-Cell Lymphoma

Primary Cutaneous CD8⁺ Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma

Primary Cutaneous CD4⁺ Small/Medium T-Cell Lymphoma

T-Cell Prolymphocytic Leukemia

T-Cell Large Granular Lymphocytic Leukemia (T-LGL)

Peripheral T-Cell Lymphoma, Not Otherwise Specified

Angioimmunoblastic T-Cell Lymphoma

Anaplastic Large Cell Lymphoma, ALK⁺

Anaplastic Large Cell Lymphoma, ALK^-

EBV-Positive T-Cell Lymphoproliferative Disorders of Childhood

Adult T-Cell Leukemia/Lymphoma (ATLL)

Enteropathy-Associated T-Cell Lymphoma (EATL)

Hepatosplenic T-Cell Lymphoma

Subcutaneous Panniculitis-Like T-Cell Lymphoma

E. NK-Cell Neoplasms

Extranodal NK/T-Cell Lymphoma

Aggressive NK-Cell Leukemia

Chronic Lymphoproliferative Disorder of NK Cells

F. Classical Hodgkin Lymphoma

Nodular Sclerosis Type

Mixed Cellularity Type

Lymphocyte-Rich Type

Lymphocyte-Depleted Type

Nodular Lymphocyte-Predominant Hodgkin Lymphoma

X. IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS

A. HIV-Associated Lymphoproliferative Disorders

HIV Lymphadenitis

HIV-Associated Lymphoproliferative Disorders

B. Post-Transplant Lymphoproliferative Disorders (PTLDs)

Early, Polymorphic, Monomorphic, and Hodgkin Types

C. Primary Immunodeficiency-Associated Lymphoproliferative Disorders

Overview of Primary Immunodeficiency-Associated Lymphoproliferative Disorders

Autoimmune Lymphoproliferative Syndrome (ALPS)

XI. MYELOID NEOPLASMS

A. Myeloproliferative Disorders

Chronic Myelogenous Leukemia (CML)

Chronic Neutrophilic Leukemia (CNL)

Polycythemia Vera (PV)

Essential Thrombocythemia (ET)

Primary Myelofibrosis (PMF)

Chronic Eosinophilic Leukemia (CEL)

Mastocytosis

B. Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, or FGFR1

C. Myelodysplastic/Myeloproliferative Neoplasms

Chronic Myelomonocytic Leukemia

Atypical Chronic Myeloid Leukemia

Juvenile Myelomonocytic Leukemia (JMML)

D. Myelodysplastic Syndromes

Refractory Anemia with Unilineage Dysplasia

Refractory Anemia with Ring Sideroblasts

Refractory Cytopenia with Multilineage Dysplasia

Refractory Anemia with Excess Blasts (RAEB)

Myelodysplastic Syndrome (MDS) with Isolated del(5q)

E. Acute Myeloid Leukemia with Recurrent Genetic Aberrations

AML with t(8;21)(q22;q22); RUNX1/RUNX1T1

Acute Myeloid Leukemia (AML) with inv (16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11

Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML-RARA

Acute Myeloid Leukemia (AML) with t(9;11)(p22;q23); MLLT3-MLL

Acute Myeloid Leukemia (AML) with t(6;9)(p23;q34); DEK-NUP214

Acute Myeloid Leukemia with (AML) inv(3)(q21q26.6) or t(3;3)(q21;q26.2);RPN1-EVI1

Acute Myeloid Leukemia (AML) (Megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1

Acute Myeloid Leukemia (AML) with Mutated NPM1

Acute Myeloid Leukemia (AML) with Mutated CEBPA

F. Acute Myeloid Leukemia, Not Otherwise Specified

AML with Minimal Differentiation

Acute Myeloid Leukemia (AML) without Maturation

Acute Myeloid Leukemia (AML) with Maturation

Acute Myelomonocytic Leukemia

Acute Monoblastic Leukemia

Acute Monocytic Leukemia

Acute Erythroid Leukemia, Erythroid/Myeloid Subtype

Acute Erythroid Leukemia, Pure Erythroid Leukemia Subtype

Acute Megakaryoblastic Leukemia

G. Acute Myeloid Leukemia (AML) with Myelodysplasia-Related Changes

H. Therapy-Related Myeloid Neoplasms

I. Myeloid Sarcoma

J. Myeloid Proliferations Related to Down Syndrome (DS)

K. Blastic Plasmacytoid Dendritic Cell Neoplasm

XII. HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS

Histiocytic Sarcoma

Langerhans Cell Histiocytosis

Langerhans Cell Sarcoma

Follicular Dendritic Cell Sarcoma

Interdigitating Dendritic Cell Sarcoma

Indeterminate Dendritic Cell Tumor

Fibroblastic Reticular Cell Tumor

XIII. THYMOMA AND THYMIC CARCINOMA

Thymoma

Thymic Carcinoma