This comprehensive New Edition describes all of the latest scientific and clinical advances in the field of inflammatory bowel disease (IBD). A new editorial team-joined by a superb group of international authorities-examine every aspect of IBD-including etiology and pathogenesis, diagnosis and evaluation, medical and surgical therapy, and more. A wealth of expanded coverage, additional international contributors, extensive updating throughout, and numerous diagnostic and therapeutic algorithms make this an essential resource.
1. Intestinal epithelia barrier function: Characteristics and responses to neutrophil transeptithelial migration 2. Epithelial restitution and healing 3. Epithelial/microbial interactions 4. Epithelial/immune cell interactions 5. Regulatory T lymphocytes and dendritic cells 6. T lymphocyte trafficking 7. Leukocyte, platelet and endothelial cell interactions in inflammatory bowel disease
Section II. Etiology and pathogenesis
8. Genetics - molecular and chromosomal considerations 9. Animal models 10. Microbial influences on chronic intestinal inflammation 11. Mechanisms of tissue injury 12. Cytokines and inflammatory mediators 13. T lymphocyte dysregulation 14. Neuro-immune interactions in the inflamed bowel 15. Fibrogenesis 16. Cancer - molecular considerations
Section III. Epidemiology, Clinical Features and Natural History
17. Epidemiology 18. Clinical genetics of inflammatory bowel disease 19. Clinical features and natural history of ulcerative colitis 20. Clinical features and natural history of Crohns disease 21. Clinical features and natural history of pediatric inflammatory bowel disease 22. Physiologic consequences of surgical treatment for inflammatory bowel disease 23. Fertility and Pregnancy 24. Psychosocial factors
Section IV. Diagnosis and Evaluation
25. Differential diagnosis of inflammatory bowel disease 26. Endoscopy 27. Pathology 28. Radiology 29. Serology and laboratory markers of disease activity
Section V. Medical Therapy
30. Assessment of disease activity and clinical trial design 31. Quality of life and pharmacoeconomics 32. Clinical pharmacology 33. Medical therapy for ulcerative colitis 34. Medical therapy for Crohns disease 35. Medical and nutritional therapy for pediatric inflammatory bowel disease 36. Nutrition 37. Developing therapies for inflammatory bowel disease
Section VI. Surgical Therapy
38. Indications for surgery: A gastroenterologists opinion 39. Indications for surgery: A surgeons opinion 40. Surgical management of ulcerative colitis 41. Surgical management of Crohns disease 42. Management of enterostomy appliances
Section VII. Complications and Associated Diseases