IBS is a functional bowel disorder characterized by symptoms of abdominal pain or discomfort and associated with disturbed defecation. The syndrome is understood in terms of multiple physiological determinants contributing to a common set of symptoms rather than as a single disease entity. Current and future diagnostic approaches and treatments will depend on identifying the specific pathophysiological subgroups contributing to these symptoms. This issue is devoted to the diagnosis, treatment, and managment of this disorder.
1. Definition and Classification of IBS: Current Consensus and Controversies (Longstreth) 2. Diagnosis of IBS Around the World: Prevalence, Incidence, Natural History, Health Care Seeking and Risk Factors (Chey) 3. Epidemiology Testing in the Patient with Suspected IBS: How Much Is Enough? (Talley) 4. Is IBS a Low-Grade Inflammatory Bowel Disease? (Verdu) 5. Disturbances of Motility and Visceral Hypersensitivity in IBS: Biological Markers and Epiphenomenon? (Quigley) 6. The Pathogenesis of Bloating and Visible Distention in IBS (Malagelada) 7. Brain Responses to Visceral and Somatic Stimuli in IBS: A CNS Disorder? (Chang) 8. Psychiatric and Psychological Dysfunction in IBS and the Role of Psychological Treatments (Drossman) 9. Diet and IBS: Is There a Role for Diet Manipulation? (Whorwell) 10. Efficacy of Current Drug Therapies in IBS: What Works and What Doesnt (Schoenfeld) 11.Genetics and Genotypes in IBS: Implications for Diagnosis and Treatment (Camilleri) 12. Potential Future Therapies for IBS: Will Disease Modifying Therapy as Opposed to Symptomatic Control Become a Reality? (Spiller)
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