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New Developments in Glycomedicine
Proceedings of the 4th Hirosaki International Forum of Medical Science, Hirosaki, Japan, 17 October 2000, ICS 1223
9780444506030
Dostawa
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Opis
In the post genome times of the 21st century, the significance of research in sugar chains will greatly increase for both medical research and clinical applications. Genetic manipulation now enables us to make bacteria produce mammalian proteins. However, the outcome never reveals the biological function of the protein, because the bacteria do not produce the same sugar chains as mammalian cells, and these are incomplete. Therefore, it is necessary to recognize and understand the importance of sugar chains.
Szczegóły produktu
47932
9780444506030
9780444506030
Opis
- Rok wydania
- 2001
- Numer wydania
- 1
- Oprawa
- twarda
- Liczba stron
- 300
- Waga (g)
- 721
- Preface.
Chairmans Address.
Metabolism of glycolipids, sialic acid and pathology.
Catabolism of GM2 in man and mouse (Y.-T. Li, S.-C. Li). The Gm2 gangliosidoses: pathophysiology to therapy (R.L. Proia). Microglial activation and inflammatory reaction proceding neurodegeneration in Sandhoff disease (R. Wada, C. Tifft, R. Proia). Tissue specific control of glyco-chains (A. Suzuki et al.). Transcriptional control of mammalian sialidase genes (K. Yamaguchi et al.). Synthesis of novel sialic acid-containing polymers as inhibitors of hemagglutination (Y. Makimura, G. Zhonghong, R. Roy). Study of autoantibody against advanced glycation endproducts of the Maillard reaction (N. Araki et al.). Analysis of carboxymethyl-lysine in AGE-protein of the Maillard reaction (T. Araki et al.). Characterization of yeast mutant #64: occurrence of shorter-chain C55-60 polyprenol (S. Tateyama, H. Sagami).
Roles of N-glycans in tissues.
Changes in gene expression of â-1,4-galactosyltransferases by malignant transformation (K. Furukawa). Chemical structure of the carbohydrate moiety of fucose-rich glycopeptides from human pancreatic juice (S. Yoshihara et al.). New materials and techniques for glycomedicine (T. Inazu). Multimerization and collagen binding of vitronectin is modulated by its glycosylation (K. Asanuma, F. Arisaka, H. Ogawa). Changes in clycosylation and collagen binding of vitronectin in liver cirrhosis (R. Suzuki et al.). Detection of tissue specific sugar chains by two-dimensional HPLC sugar mapping of pyridylaminated sugar chains (S.-i. Nakakita, K. Ikenaka, S. Hase). The role of protein kinases in glycoprotein GMP-140 expression on activated human platelets (M. Shoji et al.).
Mucin as a biogenic messenger.
MUC1 as a human tumor marker (K. Imai et al.). Characterization of mucin in gut lavage fluid obtained from inflammatory bowel disease (H. Saitoh et al.). Analysis of p-nitrophenyl N-acetly-á-D-Galactosaminide-induced oligosaccharides (A. Matsuki, J. Kukidome, A. Munakata). Convenient method for structural determination of glycans related to diseases (I. Ishii-Karakasa). Structural analysis of the oligosaccharide units of xyloglucan and their efforts on growth of COLO 201 human tumor cells (Y. Kato et al.). Functional analysis of cellulose-synthase-like genes (T. Konishi, F. Sakaki, T. Hayashi).
Roles of proteoglycans in tissue organization.
The rationale for and pre-clinical results of chrondroitinase ABC in chemonucleolysis (M. Brown). Age-related changes in glycosaminoglycan chains of nucleus pulposus proteoglycan of baboon vertebral discs (W. Nakamura, K. Takeuchi, S. Harata). Regulation of hyaluronan synthases: negative effects on the hyaluronan synthetic activity of the mutated HAS protein that has no enzymatic activity (T. Sawai et al.). Proteoglycans in the nucleus pulposus after chondroitinase ABC treatment (A. Ono, T. Nitobe, S. Harata). The role of proteoglycans in ossification of spinal ligament (M. Yukawa et al.). Significance of sulfate-O-3-Xyl-MU synthesized by cultured human skin fibroblasts (T. Tazawa et al.). Binding between calcium ions and chondroitin sulfate chains of salmon nasal cartilage glycosaminoglycan (H. Uchisawa et al.). Effect of proteoglycan on experimental colitis (M. Majima et al.).
New developments of glycosaminoglycans for clinical applications.
Use of glycosaminoglycans in the treatment of interstitial cystitis - a strategy to improve efficacy (V.P. Bhavanandan et al.). Enzymatic reconstruction of glycosaminoglycan oligosaccharides (K. Takagaki et al.). 4-Methylumbelliferone inhibits hyaluronate synthesis in cultured fibroblasts from the human uterine cervix (K. Tanaka et al.). Photocrosslinkable chitosan: an effective adhesive with surgical applications (M. Ishihara et al.). Effects of hyaluronan on matrix metalloproteinase activities in skin fibroblasts (T. Nakamura, A. Sakamoto, T. Ishikawa). Hyaluronan knockdown extracellular matrix of cultured human skin fibroblast by using of 4-methylumbelliferone (Y. Endo et al.). Effect of 4-methylumbelliferone on hyaluronan synthesis of streptococcus equi FM100 (I. Kakizaki et al.). Serum hyaluronic acid level is a good marker for evaluating the process of joint destruction in rheumatoid arthritis (T. Sawai, M. Uzuki). A comparison of the affinity of sodium hyaluronate of various molecular weights for degenerated cartilage: a histochemical study using hyaluronic acid binding protein (M. Uzuki, T. Sawai).
Index of authors. Keyword Index.
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