In this issue of Neuroimaging Clinics, guest editors Drs. Christopher Filippi and Jane McEniery bring their considerable expertise to the topic of Updates on Pediatric Brain and Spine Tumors. Top experts discuss changes to the WHO classification for pediatric brain and spine tumors; circumscribed astrocytic tumors; glioneuronal tumors; congenital neonatal tumors; radiomics and AI for pediatric brain tumor; tumor predisposition syndromes; and more.