Although initially thought to be a deleterious influence on tissue repair and remodelling, recent studies have shown the versatility of the mast cell in modulating tissue responses in a beneficial as well as an adverse manner. Hence it is clear that understanding mast cell biology in the context of normal and abnormal tissue repair and remodelling will be crucial to preventing and treating cardiovascular disease. This book brings together world-renowned scientists in the field of mast cell biology to present the current knowledge regarding the role of these enigmatic cells in cardiovascular disease, and innovative research approaches to tackle this field of cardiovascular investigation.
Introduction:: Jacob Joseph; Mast Cells, Local Renin Angiotensin System & Cardiovascular Disease; Mast Cell Regulation of Cardiovascular Inflammation I:: Cognate & Non-cognate Interactions; Mast Cell Regulation of Cardiovascular Inflammation II:: Infection & Innate Immunity; Mast Cells & Tissue Remodeling; The Mast Cell & its Role in Atherosclerosis & Coronary Artery Disease; The Role of Mast Cells in the Infarcted Myocardium; The Role of Mast Cells in Mediating Myocardial Remodeling in Response to Sustained Volume Overload; Role of Mast Cells in Radiation-Induced Heart Disease; Mast Cells, Inflammation, & Myocardial Disease; Are Mast Cells a Common Denominator in the Pathogenesis of Endomyocardial Fibrosis?; Human Heart Mast Cell & Its Role in Cardiovascular Disease; Mast Cells:: Masters of Ceremony in Cardiovascular Pathophysiology?; Index.
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