Adult Stem Cell Standardization

Stem cell research and technology represents a major challenge for treating otherwise non-curable patients. A decade of intensive research has demonstrated that initial hopes based more on the will to succeed than on solid scientific bases can be translated into factual techniques only by adopting more rigorous procedures and strategies. Among other major impediments, the failure so far experienced in applying stem cell technologies to repair parenchymal organs can be ascribed to the lack of sufficient knowledge of basic mechanisms, but also to the lack of standardized criteria and protocols. Very often different laboratories follow their own "recipe" using erratic nomenclature and non-comparable, if not confusing, experimental protocols. All of this makes it difficult for them to learn from each other and, ultimately, hampers the advance of knowledge on stem cell behaviour. The ambitious goal of this book is to gather the most innovative and scientifically-robust knowledge and technologies on stem cells, and involve investigators from academy and industry in formulating recommendations to standardize the isolation and manipulation of stem cells using solid and well-documented knowledge rather than fragmentary and often unrepeatable experimental reports.