Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrigs disease is an adult-onset fatal neurodegenerative disease characterised by progressive apoptosis of upper and lower motor neurons in the brain, brainstem and spinal cord. This results in paralysis of bulbar, limb, thoracic and abdominal skeletal muscles, and death within 25 years of diagnosis. In this book, the authors present current research on the symptoms, treatment and prognosis of ALS. Topics include audiological profiles and hearing loss in ALS patients; the role of the lipid transcription factor and sterol regulatory element binding protein 1 (SREBP1) in ALS; molecular targeted therapy for ALS; physical and communication disabilities in ALS; psychological interventions for ALS patients and their caregivers; and a study of ALS progression and propagation.
Preface; The Audiological Profile & Perceptions of Hearing Loss in Individuals with Amyotrophic Lateral Sclerosis; Role of Lipid Transcription Factor, Sterol Regulatory Element Binding Protein 1 (SREBP1) in ALS:: Potential Therapeutic Interventions; Molecular Targeted Therapy against Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis:: Exploring the Impact of Decreased Speech Intelligibility on Marital Communication; Psychological Interventions in Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis & Lipid Peroxidation; The Spread Pattern & Survival in Sporadic ALS:: How Does ALS Progress or Propagate?; Index.
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