The amputation of a limb is a surgical intervention used as a last resort to remove irreparably damaged, diseased, or congenitally malformed limbs where retention of the limb is a threat to the well-being of the individual. The procedure traumatically alters the body image, but often leaves sensations that refer to the missing body part, the phantom limb. In 50-80% of cases, these sensations are perceived as painful and referred to as ‘Phantom Limb Pain’. Direct Nerve Stimulation for Induction of Sensation and Treatment of Phantom Limb Pain provides an overview of research, experiences and results for the design, development and test of hardware and software components, and the ambition to safely implant and evaluate a novel neural interface system to combat phantom limb pain in an amputee volunteer subject.
Introduction; Phantom limb pain; Neurobiology of pain; The TIME implantable electrode; Modeling to guide implantable electrode design; Biocompatibility of the TIME electrode; Selectivity of the TIME electrode; Design of a multichannel stimulator; A psychophysical testing platform for experimental control; Clinical test of sensory stimulation for PLP treatment; Future applications of the TIME electrode.
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