Membrane Systems: For Bioartificial Organs and Regenerative Medicine

1. Natural and Synthetic Membranes

Biomedical Polymers

Preparation Techniques

Membrane Configurations

Characterization of Membrane Properties

Sterilization Procedures

2. Basic Issues in Membrane Separation for Biomedical Devices

Driving Forces in Molecular Separation

Transport through Microporous Membranes

Transport through Dense Membranes

Performance Parameters

3. Membrane Artificial Organs

Bioengineering Principles

Hemodialyser

Hemofilters

Plasmafilters

Blood Oxygenator

4. Biocompatibility Assessment

Membrane Trombogenicity

Complement Activation

Activation of Leukocytes

Inflammation Reaction

Bioincompatibility Aspects

5. Engineering of Membrane Biohybrid Organs

Computational Fluid Dynamics Analysis

Analysis of Metabolic Kinetics

Configuration of Membrane Devices

6. Membrane Biohybrid Organs

Design Concepts

Liver

Pancreas

Kidney

Lung

Cardio-vascular devices

7. Citocompatibility Assessment

Cell Response

Protein Adsorption

Cell-Membrane Interactions

Role of Membrane Properties on Cell Arrangement and Organization

Evaluation of Tissue Compatibility

8. Regulatory and Ethical Issues

Regulatory of Biomedical Membrane Devices

Ethical Issues