In this issue of Immunology & Allergy Clinics, guest editor Dr. Benjamin T. Prince brings his considerable expertise to the topic of Patient-Directed Care in Patients with Allergic and Immunologic Conditions. Top experts cover new and emerging therapies for the treatment of food allergy; how to recognize and manage the psychosocial implications of having a food allergy; when and how to tackle penicillin allergy during pregnancy; important considerations in the interpretation of diagnostic testing in allergy; and more.