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Applied Physical Pharmacy, Third Edition

Applied Physical Pharmacy, Third Edition

9781260452211
442,20 zł
420,09 zł Zniżka 22,11 zł Brutto
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Opis
Publishers Note:: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.


A complete practice-oriented introduction to physical pharmacy

Written to clearly and simply explain how drugs work, this textbook explores the fundamental physicochemical attributes and processes important for understanding how a drug is transformed into a usable product that is administered to a patient to reach its pharmacological target, and then exists the body. 

Applied Physical Pharmacy, Third Edition begins with a review of the key biopharmaceutics concepts of drug liberation, absorption, distribution, metabolism, and excretion. These concepts, and others, set the framework for the subsequent chapters that describe physicochemical properties and process related to the fate of the drug. Other physical pharmacy topics important to drug formulation are discussed in the chapters that follow, which describe dispersal systems, interfacial phenomena, and rheology. The textbook concludes with an overview of the principles of kinetics that are important for understanding the rates at which many of the processes discussed in previous chapters occur.

Chapters in this Third Edition retain the acclaimed learning aids of previous editions, including Learning Objectives, Practice Problems, Key Points, and Clinical Questions. In order to be of greater value to the pharmacy student, more clinical questions have been added, and many tables have been updated with more current products and excipients. 

Szczegóły produktu
McGraw Hill / Medical
60764
9781260452211
9781260452211

Opis

Rok wydania
2019
Numer wydania
3
Oprawa
twarda
Wymiary (mm)
183 x 244
Waga (g)
626
  • Contributors
    Preface
    1. Introduction to Biopharmaceutics
    Introduction
    Drug Disposition—The Fate of the Drug After Administration
    Ladme
    Conclusion
    Key Point
    Clinical Questions
    2. States of Matter Related to Pharmaceutical Formulations
    Introduction
    Intermolecular Forces
    States of Matter
    Stability of Solids
    Acknowledgment
    Problems
    Answers
    Key Points
    Clinical Questions
    Appendix
    3. Physical Properties of Solutions
    General Considerations
    Concentration Expressions
    Classification of Aqueous Solution Systems
    Physical Properties of Solutions
    Physiologic Applications of Colligative Properties
    Isotonic Solutions
    Sodium Chloride Equivalent Values (E)
    Problems
    Answers
    Key Points
    Clinical Questions
    Appendix
    4. Ionic Equilibria and Buffers
    Electrolytes Versus Nonelectrolytes
    Importance of Ionization in Pharmacy
    Acids and Bases
    Ionization of Water
    Ionization of Electrolytes
    Ionization of Salts
    Buffers
    Ionization of Amphoteric Electrolytes
    Ionization of Polyprotic Acids
    Activity and Activity Coefficient
    Acid–Base Titration and Titration Curve
    Problems
    Answers
    Key Points
    Clinical Questions
    Appendix
    Suggested Readings
    5. Solubility, Dissolution, and Partitioning
    Solubility
    Dissolution
    Dissolution of Particles
    Factors Affecting Drug Dissolution
    Partitioning
    Solubility Problems
    Answers
    Dissolution Problems
    Answers
    Partitioning Problems
    Answers
    Key Points
    Clinical Questions
    Appendix
    6. Mass Transport
    Introduction
    Transport Systems
    Diffusion Through a Membrane
    Significance of Diffusion
    Significance of Osmosis
    Problems
    Answers
    Key Points
    Clinical Questions
    7. Complexation and Protein Binding
    Introduction
    Types of Complexes
    Metal–Ion Coordinate Complexes
    Cyclodextrin Complexes
    Ion-Exchange Resins
    Protein–Ligand Interactions
    Plasma Protein Binding
    Problems
    Answers
    Key Points
    Clinical Questions
    Appendix
    8. Dispersed Systems
    Dispersed Systems Classified by Their Phases
    Dispersed Systems Classified by Their Particle Size
    Physical Stability of Dispersed Systems
    Summary
    Problems
    Answers
    Key Points
    Clinical Questions
    Suggested Readings
    9. Interfacial Phenomena
    Surface Tension
    Electrical Double Layer
    Adsorption
    Problems
    Answers
    Key Points
    Clinical Questions
    Appendix
    10. Rheology
    Introduction
    Newtonian Flow
    Viscosity of Newtonian Fluids
    Effect of Temperature on Viscosity
    Non-Newtonian Flow
    Thixotropy
    Viscoelasticity
    Significance of Rheology
    Viscosity Modifiers
    Problems
    Answers
    Key Points
    Clinical Questions
    Appendix
    11. Chemical Kinetics of Pharmaceuticals
    Common Drug Degradation Reactions
    Order of Reaction
    Determination of the Order of a Reaction
    Stability and Shelf-Life of Drugs
    Enzyme Catalysis Reactions
    Pharmacokinetics: An Extension of Reaction Kinetics
    Problems
    Answers
    Clinical Questions
    Suggested Readings
    Appendix: Basic Mathematical Concepts
    Equations
    Logarithmic Function
    Exponential Function
    Differentiation and Integration Functions
    Bibliography
    Mathematical Tables
    Endnotes
    Index
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