In this thoroughly revised and updated second edition, the emphasis remains on providing a practical and up-to-date guide for the practicing pathologist when evaluating peripheral blood, bone marrow and lymph node specimens from pediatric patients. Over 400 high quality colour figures aid accuratecountries, the use of molecular diagnostics, and the role of flow cytometry in diagnosis and post-therapy monitoring of hematologic malignancies. The importance of unique diagnostic features of benign and malignant hematologic disorders in children is retained, with chapters authored by experienced pediatric hematopathologists and clinical scientists drawn from major childrens hospitals across the US, Europe and Africa. The print book comes with access to the text and expandable figures online at Cambridge Core, which can be accessed via the code printed on the inside of the cover.
Introduction; Section I. General and Non-neoplastic Hematopathology: 1. Hematologic values in the healthy fetus, neonate, and child Maria A. Proytcheva; 2. Normal bone marrow Maria A. Proytcheva; 3. Disorders of erythrocyte production: nutritional deficiencies, iron deficient, and sideroblastic anemia Angela E. Thomas and Barbara J. Bain; 4. Disorders of hemoglobin synthesis thalassemias and structural hemoglobinopathies Archana M. Agarwal and Anton Rets; 5. Hemolytic anemias: immune- and non-immune-mediated hemolytic anemias, RBC membrane defects, and hereditary disorders due to RBC enzyme defects Maria A. Proytcheva; 6. Anemias in children in developing countries Simon Osongo and Elizabeth Kagotho; 7. Inherited bone marrow failure syndromes Jyotinder N. Punia, M. Tarek Elghetany and Maria A. Proytcheva; 8. Peripheral blood and bone marrow manifestations of metabolite storage diseases Andrea N. Marcogliese; 9. Reactive lymphadenopathies Maria A. Proytcheva; 10. Spleen: normal architecture and non-neoplastic and neoplastic lesions Flavia G. N. Rosado, Genevieve M. Craine, and Dennis P. OMalley; 11. Chromosome abnormalities of hematologic malignancies: a practical guide to cytogenetic analysis Katrin M. Leuer and Pamela Rathbun; Section II. Neoplastic Hematopathology: 12. Molecular diagnostics of pediatric acute leukemias in the era of high throughput sequencing Somak Roy and Erin H. Breese; 13. Immunophenotypic characterization of pediatric leukemia/lymphoma by flow cytometry including minimal residual disease detection Sunita Park and Yi Zhou; 14. Myeloproliferative neoplasms and their mimics Robert B. Lorsbach; 15. Mastocytosis and related disorders Robert B. Lorsbach; 16. Juvenile myelomonocytic leukemia and related disorders John Kim Choi; 17. Myelodysplastic syndromes Robert B. Lorsbach; 18. Acute myeloid leukemia and related precursor neoplasms Robert B. Lorsbach; 19. Hematologic abnormalities in individuals with Down syndrome John Kim Choi; 20. Lymphoblastic neoplasms Mihaela Onciu; 21. Advances in prognostication and treatment of pediatric acute leukemia - substantial revision Nobuko Hijiya and Jing Chen; 22. Bone marrow findings post-chemotherapy and hematopoietic stem cell transplantation Maria A. Proytcheva; 23. Pediatric small blue cell tumors metastatic to the bone marrow Maria A. Proytcheva; 24. Pediatric mature B-cell non-Hodgkin lymphomas Rodney R. Miles and Sherrie L. Perkins; 25. Pediatric mature T-cell and NK-cell non-Hodgkin lymphomas Rodney R. Miles and Sherrie L. Perkins; 26. Classic Hodgkin lymphoma and nodular lymphocyte predominant B-cell lymphoma Robert B. Lorsbach and Mihaela Onciu; 27. Immunodeficiency-associated lymphoproliferative disorders: congenital immune deficiencies, acquired immune deficiencies, and post-transplant lymphoproliferative disorders Michele Paessler and Brian Lockhart; 28. Histiocytic proliferations in childhood Jennifer Picarsic, Ashish Kumar, and Rebecca Marsh; 29. Cutaneous and subcutaneous lymphomas in children Jasmine Saleh, Woo Jin Lee, and Joan Guitart; Index.
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