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Endocrinology

3-Volume Set

9780721603766
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1 918,73 zł Zniżka 213,19 zł Brutto
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Opis
Revised throughout, the 5th Edition of this leading reference presents a complete and up-to-date review and analysis of all aspects of endocrinology, diabetes, and bone metabolism. Readers will also find state-of-the-art information on genetics, proteinomics, and hormone signaling, and coverage of the fields hottest topics in nearly 20 new chapters. Joined by an international team of leading experts-many new to this edition-Drs. Jameson and DeGroot provide guidance that integrates the basic science of endocrinology with clinical medicine and the practical management of endocrine disorders. A clinical focus emphasizes diagnosis and therapy.
Szczegóły produktu
Saunders
32228
9780721603766
9780721603766

Opis

Rok wydania
2005
Numer wydania
5
Oprawa
twarda
Liczba stron
4144
Wymiary (mm)
216 x 276
Waga (g)
9253
  • I. PRINCIPLES OF HORMONE ACTION

    1. Endocrinology: Impact on science and medicine


    II. GENOMICS & ENDOCRINOLOGY

    2. Hormones and gene expression: basic principles
    3. Cell division, differentiation, senescence, and death
    4. Appication of genomics and proteinomics to endocrinology
    5. Transgenic and genetic animal models
    6. Genetic syndromes in endocrinology


    III. MECHANISMS OF ENDOCRINE SIGNALING & RESPONSE

    7. Control of hormone secretion
    8. Hormone signaling via tyrosine kinase receptors
    9. Hormone signaling via cytokine receptors
    10. Hormone signaling via serine kinase receptors
    11. Hormone signaling via G-protein coupled receptors
    12. Cyclic AMP signaling pathway
    13. Second messenger signaling pathways: Phospholipids and calcium
    14. MAP kinase and growth factor signaling pathways
    15. Nuclear receptors: Sturcture, function and co-factors


    IV. NEUROENDOCRINOLOGY & PITUITARY DISEASE

    16. Development of the pituitary
    17. Prolactin
    18. ACTH
    19. Endocrine rhythms and the clock
    20. Hypothalamic syndromes
    21. Evaluation of hypothalamic and pituitary masses
    22. Hypopituitarism
    23. Acromegaly
    24. Cushings Disease and Syndrome
    25. Non-functioning ademonas and gonadotrophinomas
    26. TSH-producing adenomas
    27. Prolactinoma
    28. Pituitary surgery
    29. Evaluation and management of childhood hypothalamic and pituitary tumors
    30. Posterior pituitary, diabetes insipidus, SIADH
    31. The pineal gland: basic physiology and clinical implications


    V. GROWTH & MATURATION

    32. Growth hormone
    33. Regulation of GH secretion
    34. ICH-I, IGF-BPs, and IFG-II
    35. Other growth factors
    36. Growth and maturation
    37. Growth hormone deficiency in children
    38. Growth hormone deficiency in adults


    VI. IMMUNOLOGY & ENDOCRINOLOGY

    39. Autoimmune endocrine disease
    40. Interactions of the Endocrine and Immune Systems
    41. Autoimmune polyglandular failure syndromes


    VII. OBESITY, ANOREXIA, AND NUTRITION

    42. Appetite regulation and thermogenesis
    43. Obesity: The problem and its management
    44. Genetics and syndromes of obesity (
    45. Anorexia Nervosa, Bulimia Nervosa, and other eating disorders
    46. Starvation and parenteral


    VIII. DIABETES MELLITUS

    47. Development of the endocrine pancreas
    48. Chemistry and biosynthesis of the islet hormones
    49. Secretion and metabolism of insulin
    50. Insulin action
    51. Glucagon and the glucagon-like peptides
    52. Integrated control of energy substrate utilization
    53. Role of the adipocyte in metabolism and endocrine function
    54. Classification and diagnosis of diabetes mellitus
    55. Type 1 (Insulin-dependent) diabetes mellitus: Etiology, pathogenesis, and natural history
    56. Type 2 diabetes mellitus: Etiology, pathogenesis, and natural history
    57. Hyperglycemia secondary to non-diabetic conditions and therapies
    58. Syndromes of insulin resistance and lipodystrophy
    59. Metabolic syndrome
    60. Treatment of Type 1 diabetes mellitus in adults
    61. Ketoacidosis and hyperosmolar coma
    62. Hypoglycemia
    63. Management of Type 2 diabetes mellitus
    64. Management of diabetes in children
    65. Pancreatic and islet transplantation
    66. Relationship of diabetic control to complications
    67. Diabetic oculopathy
    68. Diabetic neuropathy
    69. Diabetic nephropathy
    70. Diabetic foot and vascular complications


    IX. PARATHYROID GLAND, CALCIOTROPIC HORMONES & BONE METABOLISM

    71. Parathyroid hormone and parathyroid hormone-related peptide
    72. Calcitonin
    73. Vitamin D
    74. Regulation of calcium homeostasis
    75. Bone development and remodeling
    76. Genetic defects in the parathyroid axis
    77. Hyperparathyroidism: Differential diagnosis of
    78. Malignancy-associated hypercalcemia
    79. Medical treatment of hypercalcemia
    80. Surgical management of hypercalcemia
    81. Familial hypocalciuric hypercalcemia and other disorders due to calcium-sensing receptor mutations
    82. Hypoparathyroidism and pseudohypoparathyroidism
    83. Genetic defects in vitamin D metabolism and action
    84. Nephrolithiasis
    85. Genetic Defects and Disorders of Bone
    86. Bone imaging and assessment of bone density
    87. Renal osteodystrophy
    88. Osteomalacia and rickets
    89. Osteoporosis
    90. Pagets Disease of bone

    X. THYROID

    91. Development of the
    92. Thyroid-stimulating hormone and regulation of the thyroid
    93. Thyroid hormone formation
    94. Thyroid Regulatory
    95. Thyroid hormone metabolism
    96. Thyroid hormone action
    97. Throid function tests: Effects of drugs and disease on the thyroid
    98. Thyroid
    99. Autoimmune thyroid disease
    100. Graves Disease
    101. Graves Ophthalmopathy
    102. Other causes of hyperthyroidism
    103. Chronic (Hashimotos) thyroiditis
    104. Subacute and Reidels thyroiditis
    105. Hypothyroidism and myxedema coma
    106. Nonthyroidal illness syndrome
    107. Multinodular goiter
    108. Iodine defieciency
    109. Thyroid nodules and Thyroid
    110. Medullary thyroid carcinoma
    111. TSH receptor mutations
    112. Genetic Defects in Thyroid Hormone Synthesis and Action: Defects in Thyroid Hormone
    113. Thyroid Hormone Binding and Variants of Transport Proteins
    114. Resistance to thyroid hormone
    115. Surgery of the thyroid: Abberant thyroid masses


    XI. ADRENAL GLAND AND ADRENAL HORMONES

    116. The principles, pathways, and enzymes of human steroidogenesis
    117. Glucocorticoid physiology
    118. Gulcocorticoid receptors and their mechanisms of action
    119. Aldosterone: Secretion and
    120. Glucocorticoid therapy
    121. Adrenal insufficiency/Cushings Disease
    122. Adrenal causes of hypercortisolism
    123. Generalized Glucocorticoid resistance
    124. Congenital adrenal
    125. Adrenarche and adrenopause
    126. Adrenal imaging and adrenal incidentaloma
    127. Adrenal neoplasia
    128. Primary mineralocorticoid excess
    129. Mineralocorticoid deficiency
    130. Pheochromocytoma
    131. Adrenal surgery


    XII. CARDIOVASCULAR ENDOCRINOLOGY

    132. Hormones of the cardiovascular system
    133. Hormonal regulation of electrolyte and water metabolism
    134. Endocrine changes in CHF
    135. Management of lipid disorders
    136. Essential hypertension and endorine hypertension
    137. Orthostatic hypotension


    XIII. ENDOCRINE CHANGES IN CRITICALLY ILL PATIENTS

    138. Endocrine aspects of critical care


    XIV. REPRODUCTIVE ENDOCRINOLOGY AND SEXUAL FUNCTION

    139. GnRH and gonadotropins
    140. Gonadal peptides: Inhibins, activins, follistatin, MIS
    141. Regulation of gonadotropin synthesis and secretion
    142. Genetic basis of sexual differentiation
    143. Embryology and control of sex differentiation
    144. Endocrinology of sexual maturation
    145. Environmental agents and the reproductive system
    146. Diagnosis and treatment of disorders of sexual development
    147. Precocious puberty
    148. Delayed puberty
    149. Gender identity and sexual behavior


    XV. FEMALE REPRODUCTION

    150. Folliculogenesis, ovulation, and luteogenesis
    151. Ovarian hormone synthesis and secretion
    152. Estrogen and progesterone action
    153. Hormonal regulation of the menstrual cycle and mechanisms of ovulation
    154. Amenorrhea, anovulation, and dysfunctional uterine bleeding
    155. Endometriosis
    156. Female infertility: Evaluation and management
    157. Polycystic ovarian syndrome, hirsutism, and hyperandrogenism
    158. Ovulation induction and assisted reproduction
    159. Contraception
    160. Female sexual dysfunction
    161. Premenstual syndrome
    162. Mechanisms of menopause and the menopausal transition
    163. Ovarian tumors with endocrine manifestations


    XVI. ENDOCRINOLOGY OF THE BREAST

    164. Hormonal control of the breast development
    165. Benign breast disorders
    166. Breast cancer and hormonal mangement


    XVII. MALE REPRODUCTION

    167. Spermatogenesis and regulation of testicular function
    168. Androgens and androgen action
    169. Androgen receptors and androgen insensitivity syndromes
    170. Androgen deficiency disorders
    171. Cryptorchidism and hypospadias
    172. Male infertility
    173. Male sexual dysfunction
    174. Male contraception
    175. Testicular tumors with Endocrine Manifestations
    176. Use and abuse of anabolic steroids
    177. Gynecomastia
    178. Physiology and pathophysiology of androgenetic alopecia
    179. Endocrinology of the Prostate and Benign Prostatic Hyperplasia
    180. Prostate cancer


    XVIII. ENDOCRINOLOGY OF PREGNANCY

    181. Implantation and placental physiology
    182. Placental hormones
    183. Fetal and neonatal endocrinology
    184. Fuel homeostasis in the fetus and neonate
    185. Endocrinology of partuition
    186. Diabetes mellitus and pregnancy
    187. Diagnosis and treatment of thyroid disease during pregnancy
    188. Lactation
    189. Gestational trophoblastic neoplasms
    190. Hormonal changes and endocrine testing in pregnancy


    XIX. ENDOCRINE TUMOR SYNDROMES

    191. Multiple endocrine neoplasia Type 1
    192. Multiple endocrine neoplasia Types IIa and IIb
    193. Gastrointestinal hormones and tumor syndromes
    194. Carcinoid syndrome
    195. Ectopic hormone syndromes


    XX. ENDOCRINE TESTING AND ENDOCRINE DRUG

    196. Endocrine testing
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