Effect of Trace Elements in Experimental Colon Cancer

Based on the results presented in this book, and in accordance with previously published results, the authors emphasize the role of the extracellular matrix as the medium through which the processes of growth, invasion, differentiation, and cell death are regulated. Moreover, in the last chapter dedicated to the conclusions, the effect of Trace Elements zinc, selenium and manganese (OLMs) on these interrelationships is also discussed.

This book offers the reader promising basic and preclinical findings that give hope for the potential therapeutic use of OLMs in CRC (colorectal cancer) patients.

Additionally, the book opens several other avenues of research. Given that OLMs positively regulate immunity and negatively regulate tumor development and growth, one potential research direction would be to determine whether the antitumor action of OLMs is mediated by an increase in antitumor immunity.

In addition to their known nutritional properties, the trace elements Zn, Se and Mn can act on the inhibition of initiation and progression of colorectal cancer through the extracellular matrix.