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Challenges and Elucidation of Drug Solubility

Challenges and Elucidation of Drug Solubility

9781036447809
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Description
Solubility is a pivotal parameter in the pharmaceutical industry, as it directly influences the bioavailability and efficacy of drug molecules. Approximately 40% of new drug candidates exhibit poor aqueous solubility, which can result in diminished therapeutic effects and the need for higher dosages. To address this challenge, researchers have explored various techniques to enhance the solubility of poorly soluble drugs.

This comprehensive guide delves into the underlying causes of poor solubility, such as the increasing hydrophobicity and low water-solubility of lead compounds and marketed drugs. The book then systematically explores a range of solubilization approaches, including salt formation, particle size reduction, solid dispersions, and the use of drug nanoparticles. Each method is thoroughly examined, with detailed discussions on the theoretical basis, practical implementation, and the advantages and limitations of each technique.

By delving into the fundamental principles and the latest advancements in solubility enhancement, this book offers a valuable resource for pharmaceutical scientists, researchers, and industry professionals seeking to overcome the solubility hurdle and drive the development of more effective and patient-centric drug products.

Product Details
Cambridge Scholars Publishing
104780
9781036447809
9781036447809

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Rok wydania
2025
Numer wydania
1
Oprawa
twarda
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