Cancer Clinical Pharmacology provides a comprehensive account of the scientific basis of anti-cancer therapy in patients with solid tumours and haematological malignancies. An international group of experts have brought together information on the basic principles of pharmacology and tumour biology, bioanalytical aspects, pharmacokinetics, and the pharmacodynamics of anti-cancer agents. The clinical pharmacology of individual anti-cancer agents are covered, including themost important recently registered novel anti-cancer drugs. This book will prove an invaluable source of information for all trainees in oncology, haematology and internal medicine. Since cancer clinical pharmacology is a vast subject this book will be useful for all individuals involved in cancer pharmacology such as nurses, pharmacists, general pharmacologists, and cancer scientists.
Bio-analytical methods for anticancer drugs; Principles of pharmacokinetics; Clinical implications and mechanisms of variability in the response to anticancer agents; Drug development and study design; Pyrimidine antimetabolites; Purine analogs and antifolates; Alkylating agents; Epipodophyllotoxins; Anthracyclines; Taxanes; Vinca alkaloids; Topoisomerase I targeting agents; Platinum agents; Novel tyrosine kinase inhibitors: focus on Imatinib and Gefitinib; Antiendoctrine drugs used in cancer treatment; The clinical application of tumour biology;
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